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      Nanonization strategies for poorly water-soluble drugs

      , , , ,
      Drug Discovery Today
      Elsevier BV

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          Abstract

          Poor water solubility for many drugs and drug candidates remains a major obstacle to their development and clinical application. Conventional formulations to improve solubility suffer from low bioavailability and poor pharmacokinetics, with some carriers rendering systemic toxicities (e.g. Cremophor(®) EL). In this review, several major nanonization techniques that seek to overcome these limitations for drug solubilization are presented. Strategies including drug nanocrystals, nanoemulsions and polymeric micelles are reviewed. Finally, perspectives on existing challenges and future opportunities are highlighted. Published by Elsevier Ltd.

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          Author and article information

          Journal
          Drug Discovery Today
          Drug Discovery Today
          Elsevier BV
          13596446
          April 2011
          April 2011
          : 16
          : 7-8
          : 354-360
          Article
          10.1016/j.drudis.2010.02.009
          20206289
          5af28152-012d-468d-aa14-c34d3f6f31d3
          © 2011

          https://www.elsevier.com/tdm/userlicense/1.0/

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