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Abstract
Poor water solubility for many drugs and drug candidates remains a major obstacle
to their development and clinical application. Conventional formulations to improve
solubility suffer from low bioavailability and poor pharmacokinetics, with some carriers
rendering systemic toxicities (e.g. Cremophor(®) EL). In this review, several major
nanonization techniques that seek to overcome these limitations for drug solubilization
are presented. Strategies including drug nanocrystals, nanoemulsions and polymeric
micelles are reviewed. Finally, perspectives on existing challenges and future opportunities
are highlighted.
Published by Elsevier Ltd.