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      Chloroquine Autophagic Inhibition Rebalances Th17/Treg-Mediated Immunity and Ameliorates Systemic Lupus Erythematosus.

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          Abstract

          Imbalanced cellular immunity is critical to the pathogenesis of systemic lupus erythematosus (SLE). Recently, autophagy has emerged as a key homeostatic mechanism in T lymphocytes. This study was conducted to explore the impact of autophagy on the Th17/ regulatory T (Treg) immune imbalance in SLE.

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          Author and article information

          Journal
          Cell. Physiol. Biochem.
          Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
          S. Karger AG
          1421-9778
          1015-8987
          2017
          : 44
          : 1
          Article
          000484955
          10.1159/000484955
          29141242
          5b2a86c3-094e-4c1e-a37a-1cec2d755782
          History

          Hydroxychloroquine (chloroquine),Systemic lupus erythematosus,Th17,Treg,Autophagy

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