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      Alpha-1-Antichymotrypsin in Renal Biopsies

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          Abstract

          α<sub>1</sub>-Antichymotrypsin (α<sub>1</sub>-AK) and α<sub>r</sub>antitrypsin (α<sub>1</sub>-AT) represent a defense mechanism to protect the tissues from proteolytic enzyme activity. We studied the implication of α<sub>1</sub>-AK and α<sub>1</sub>-AT in glomeruli of patients with different nephropathies based on the analysis of 52 paraffin-embedded renal biopsies with α<sub>1</sub>-AK and α<sub>1</sub>-AT antisera. The results demonstrate an intense α<sub>1</sub>-AK glomerular staining in renal biopsies from patients with minimal-change disease, while a minor staining of this protein was found in the other nephropathies. No significant evidence of α<sub>1</sub>-AT deposits was observed in our cases. Our findings suggest that when α-AK is lacking in glomeruli the defense mechanisms against proteolytic enzymes may not be efficient enough to protect the glomerular structures and limit the damage. Since α<sub>1</sub>-AK is a reactant of the acute phase of inflammation, it may be considered as a marker of activity for monocyte-macrophages in glomerular damage.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1990
          1990
          10 December 2008
          : 56
          : 4
          : 387-390
          Affiliations
          aDepartment of Nephrology and bInstitute of Pathology, S. Bortolo Hospital, Vicenza, Italy
          Article
          186180 Nephron 1990;56:387–390
          10.1159/000186180
          2079996
          © 1990 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 4
          Categories
          Original Paper

          Cardiovascular Medicine, Nephrology

          Renal biopsy, α1-Antichymotrypsin, Immunohistochemistry

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