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      Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis Through Adipose Tissue Crosstalk

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          Abstract

          Metabolism research has made tremendous progress over the last several decades in establishing the adipocyte as a central rheostat in the regulation of systemic nutrient and energy homeostasis. Operating at multiple levels of control, the adipocyte communicates with organ systems to adjust gene expression, glucoregulatory hormone exocytosis, enzymatic reactions and nutrient flux to equilibrate the metabolic demands of a positive or negative energy balance. The identification of these mechanisms has great potential to identify novel targets for the treatment of diabetes and related metabolic disorders. Herein, we review the central role of the adipocyte in the maintenance of metabolic homeostasis highlighting three critical mediators: adiponectin , leptin , and fatty acids.

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          Author and article information

          Journal
          101233170
          32527
          Cell Metab
          Cell Metab.
          Cell metabolism
          1550-4131
          1932-7420
          19 April 2016
          10 May 2016
          10 May 2017
          : 23
          : 5
          : 770-784
          Affiliations
          [1 ]Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas
          Author notes
          [* ]Corresponding author: philipp.scherer@ 123456utsouthwestern.edu , Telephone: (214) 648-8715, Fax: (214) 648-8720
          Article
          PMC4864949 PMC4864949 4864949 nihpa778546
          10.1016/j.cmet.2016.04.011
          4864949
          27166942
          5b492be8-28b4-4c47-afd0-981c2a91350e
          History
          Categories
          Article

          lipid signaling,adipokines,adiponectin,leptin
          lipid signaling, adipokines, adiponectin, leptin

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