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      Galectin-7 acts as an adhesion molecule during implantation and increased expression is associated with miscarriage.

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          Abstract

          Galectins are expressed at the fetal-maternal interface and have multiple roles including during blastocyst implantation. The expression of galectin-7 however has not been investigated in the uterus. We aimed to localise galectin-7 to the endometrium of women with normal fertility and with a history of miscarriage and prospectively determine whether serum levels are altered in women who subsequently miscarry. We also investigated the role of galectin-7 on trophoblast-endometrial epithelial cell adhesion.

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          Author and article information

          Journal
          Placenta
          Placenta
          1532-3102
          0143-4004
          Mar 2014
          : 35
          : 3
          Affiliations
          [1 ] MIMR-PHI Institute of Medical Research, Clayton, VIC, Australia; Monash University, Clayton, VIC, Australia. Electronic address: ellen.menkhorst@princehenrys.org.
          [2 ] MIMR-PHI Institute of Medical Research, Clayton, VIC, Australia; Monash University, Clayton, VIC, Australia.
          [3 ] Obstetrics and Gynecology, University of Melbourne, Melbourne, Australia.
          Article
          S0143-4004(14)00005-8
          10.1016/j.placenta.2014.01.004
          24522232
          5b57954d-7f22-4d03-96ce-cd5809c8e51a
          Copyright © 2014 Elsevier Ltd. All rights reserved.
          History

          Blastocyst,Endometrium,Luminal epithelium,Pregnancy,Trophoblast,Uterus

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