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      Evaluation and Management of Women and Newborns With a Maternal Diagnosis of Chorioamnionitis: Summary of a Workshop.

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          Abstract

          In January 2015, the Eunice Kennedy Shriver National Institute of Child Health and Human Development invited an expert panel to a workshop to address numerous knowledge gaps and to provide evidence-based guidelines for the diagnosis and management of pregnant women with what had been commonly called chorioamnionitis and the neonates born to these women. The panel noted that the term chorioamnionitis has been used to label a heterogeneous array of conditions characterized by infection and inflammation or both with a consequent great variation in clinical practice for mothers and their newborns. Therefore, the panel proposed to replace the term chorioamnionitis with a more general, descriptive term: "intrauterine inflammation or infection or both," abbreviated as "Triple I." The panel proposed a classification for Triple I and recommended approaches to evaluation and management of pregnant women and their newborns with a diagnosis of Triple I. It is particularly important to recognize that an isolated maternal fever is not synonymous with chorioamnionitis. A research agenda was proposed to further refine the definition and management of this complex group of conditions. This article provides a summary of the workshop presentations and discussions.

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          Author and article information

          Journal
          Obstet Gynecol
          Obstetrics and gynecology
          Ovid Technologies (Wolters Kluwer Health)
          1873-233X
          0029-7844
          Mar 2016
          : 127
          : 3
          Affiliations
          [1 ] Pregnancy and Perinatology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland; the Department of Obstetrics and Gynecology, University of Texas Medical Branch at Galveston, Galveston, Texas; the Department of Pediatrics, Columbia University, New York, New York; the Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois; the Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio; the Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, New Mexico; and the Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, University of Utah Health Sciences Center, Salt Lake City, Utah.
          Article
          NIHMS738406
          10.1097/AOG.0000000000001246
          4764452
          26855098
          5b6266b9-1a1c-4050-8670-b8df5237c640
          History

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