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      Beta2-adrenoceptors on the glial cells mediate the induction of interleukin-1beta mRNA in the rat brain.

      Brain research. Molecular brain research
      Adrenergic beta-Agonists, administration & dosage, pharmacology, Animals, Brain, physiology, Cerebral Ventricles, drug effects, Dobutamine, Injections, Intraventricular, Interleukin-1, biosynthesis, Isoproterenol, Male, Meninges, Neuroglia, RNA, Messenger, Rats, Rats, Sprague-Dawley, Receptors, Adrenergic, beta-1, Receptors, Adrenergic, beta-2, Transcription, Genetic

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          Abstract

          Interleukin-1beta mRNA was induced by i.c.v. injection of the beta-adrenoceptor agonist isoproterenol. Lower doses of procaterol, a beta2-adrenoceptor agonist showed stronger induction of the mRNA than isoproterenol. These inductions were primarily observed in the glial cells. On the other hand, the beta1-adrenoceptor agonist dobutamine induced expression of this mRNA only in the meninges. These results suggest the existence of a system for regulation of interleukin-1beta gene expression via beta2-adrenoceptors in the brain parenchyma.

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