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      Anthracycline extravasation injuries: management with dexrazoxane

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          Abstract

          The application of anthracyclines in anticancer therapy may result in accidental extravasation injury and can be a serious complication of their use. Tissue necrosis with skin ulceration is a possible outcome in the inadvertent extravasation of anthracyclines during intravenous administration. Until recently, there has been no effective treatment against the devastating effect of extravasated anthracycline. Preclinical and clinical studies are leading to the clinical implementation of dexrazoxane as the first and only proven antidote in anthracycline extravasation. In two multicenter studies dexrazoxane has proven to be highly effective in preventing skin necrosis and ulceration. This review focuses on the development and management of dexrazoxane in anthracycline extravasation injuries.

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          Author and article information

          Journal
          Ther Clin Risk Manag
          Therapeutics and Clinical Risk Management
          Therapeutics and Clinical Risk Management
          Dove Medical Press
          1176-6336
          1178-203X
          2009
          2009
          20 May 2009
          : 5
          : 361-366
          Affiliations
          Clinic for Internal Medicine IV, Department for Oncology and Haematology, University Hospital Halle, Halle, Germany
          Author notes
          Correspondence: Karin Jordan, Clinic for internal Medicine IV, Department for Oncology and Haematology, University Hospital Halle, Ernst-Grube-Str. 40, 06120 Halle (Saale), Germany, Tel +49 (0) 345/557-2924, Fax +49 (0) 345/557-2950, Email karin.jordan@ 123456medizin.uni-halle.de
          Article
          tcrm-5-361
          2697522
          19536310
          © 2009 Jordan et al, publisher and licensee Dove Medical Press Ltd.

          This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

          Categories
          Review

          Medicine

          necrosis, anthracyclines, extravasation, dexrazoxane

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