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      Quercetin attenuates neuronal autophagy and apoptosis in rat traumatic brain injury model via activation of PI3K/Akt signaling pathway.

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          Abstract

          Neuronal autophagy and apoptosis play an irreplaceable role in brain injury pathogenesis and may represent a hopeful target for treatment. Previous studies have demonstrated that administration of quercetin-attenuated brain damage in a variety of brain injury models including traumatic brain injury (TBI). However, whether PI3K/Akt signaling pathway mediates the neuroprotection of quercetin following TBI is not well clarified. We sought to propose a hypothesis that quercetin could attenuate neuronal autophagy and apoptosis via enhancing PI3K/Akt signaling.

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          Author and article information

          Journal
          Neurol. Res.
          Neurological research
          Informa UK Limited
          1743-1328
          0161-6412
          Oct 03 2016
          Affiliations
          [1 ] a Department of Neurosurgery , Central Hospital of Cangzhou , Cangzhou , People's Republic of China.
          [2 ] b Department of Neurosurgery , Second Hospital of Hebei Medical University , Shijiazhuang , People's Republic of China.
          Article
          10.1080/01616412.2016.1240393
          27690831
          5b9af240-c907-4cda-aeb8-23800abadb29
          History

          Traumatic brain injury,PI3K/Akt,Quercetin,Apoptosis,Autophagy

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