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      Taraxastane-type triterpenoids from the medicinal and edible plant Cirsium setosum

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          Abstract

          Guided by TNF- α secretion inhibitory activity assay, four taraxastane-type triterpenoids, including two new ones, 22-oxo-20-taraxasten-3 β, 30-diol ( 1) and 22 α-hydroxy-20-taraxasten-30 β, 30-triol ( 2), have been obtained from an active fraction of the petroleum ether-soluble extract of the the medicinal and edible plant Cirsium setosum. Their structures were elucidated by spectroscopic data and CD data analysis. In the TNF- α secretion inhibitory activity assay, compounds 1 and 2 were active with the IC 50 of 2.6 and 3.8 μmol·L -1, respectively. In addition, compounds 1 and 2 showed moderately selective cytotoxicity against the human ovarian cancer (A2780) and colon cancer (HCT-8) cell lines.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier
          1875-5364
          20 January 2019
          : 17
          : 1
          : 22-26
          Affiliations
          1 College of Pharmaceutical Sciences, Qinghai University for Nationalities, Xining 810000, China
          2 Beiijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, China
          3 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
          Author notes
          *Corresponding author: SHANG Xiao-Ya, E-mails: shangxiaoya@ 123456buu.edu.cn ; LIN Sheng, lsznn@ 123456imm.ac.cn

          ΔThese authors contributed equally to this work

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(19)30005-6
          10.1016/S1875-5364(19)30005-6
          Copyright © 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: Key projects of the Beijing Natural Sciences Foundation and Beijing Municipal Education Committee
          Award ID: KZ201811417049
          Funded by: National Natural Science Foundation of China
          Award ID: 81522050
          Award ID: 81773589
          Award ID: 81760783
          Funded by: Science and Technology program of Qinghai
          Award ID: 2018-ZJ-739
          Funded by: Scientific Research Common Program of Beijing Municipal Commission of Education
          Award ID: KM201811417008
          This work were supported by the Key projects of the Beijing Natural Sciences Foundation and Beijing Municipal Education Committee (No. KZ201811417049); the National Natural Science Foundation of China (Nos. 81522050, 81773589 and 81760783); the Science and Technology program of Qinghai (No. 2018-ZJ-739), and the Scientific Research Common Program of Beijing Municipal Commission of Education (No. KM201811417008).
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