49
views
0
recommends
+1 Recommend
1 collections
    1
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Taraxastane-type triterpenoids from the medicinal and edible plant Cirsium setosum

      research-article

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Guided by TNF- α secretion inhibitory activity assay, four taraxastane-type triterpenoids, including two new ones, 22-oxo-20-taraxasten-3 β, 30-diol ( 1) and 22 α-hydroxy-20-taraxasten-30 β, 30-triol ( 2), have been obtained from an active fraction of the petroleum ether-soluble extract of the the medicinal and edible plant Cirsium setosum. Their structures were elucidated by spectroscopic data and CD data analysis. In the TNF- α secretion inhibitory activity assay, compounds 1 and 2 were active with the IC 50 of 2.6 and 3.8 μmol·L -1, respectively. In addition, compounds 1 and 2 showed moderately selective cytotoxicity against the human ovarian cancer (A2780) and colon cancer (HCT-8) cell lines.

          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier
          1875-5364
          20 January 2019
          : 17
          : 1
          : 22-26
          Affiliations
          [1] 1 College of Pharmaceutical Sciences, Qinghai University for Nationalities, Xining 810000, China
          [2] 2 Beiijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, China
          [3] 3 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
          Author notes
          *Corresponding author: SHANG Xiao-Ya, E-mails: shangxiaoya@ 123456buu.edu.cn ; LIN Sheng, lsznn@ 123456imm.ac.cn

          ΔThese authors contributed equally to this work

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(19)30005-6
          10.1016/S1875-5364(19)30005-6
          30704619
          5b9d03bc-3f81-4aa5-9369-f1158cc7bc43
          Copyright © 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          History
          : 01 October 2018
          Funding
          Funded by: Key projects of the Beijing Natural Sciences Foundation and Beijing Municipal Education Committee
          Award ID: KZ201811417049
          Funded by: National Natural Science Foundation of China
          Award ID: 81522050
          Award ID: 81773589
          Award ID: 81760783
          Funded by: Science and Technology program of Qinghai
          Award ID: 2018-ZJ-739
          Funded by: Scientific Research Common Program of Beijing Municipal Commission of Education
          Award ID: KM201811417008
          This work were supported by the Key projects of the Beijing Natural Sciences Foundation and Beijing Municipal Education Committee (No. KZ201811417049); the National Natural Science Foundation of China (Nos. 81522050, 81773589 and 81760783); the Science and Technology program of Qinghai (No. 2018-ZJ-739), and the Scientific Research Common Program of Beijing Municipal Commission of Education (No. KM201811417008).
          Categories
          Special topic

          Medicine,Pharmaceutical chemistry,Pharmacology & Pharmaceutical medicine,Complementary & Alternative medicine
          TNF-α secretion inhibitory activity,Cytotoxicity,Taraxastane-type triterpenoid, Cirsium setosum

          Comments

          Comment on this article