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      Neuropeptide Y Increases Force Development through a Mechanism That Involves Calcium Entry in Resistance Arteries

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          Abstract

          The hypothesis that neuropeptide Y (NPY) potentiates noradrenaline (NA)-induced vascular force development by increasing free intracellular Ca<sup>2+</sup> ([Ca<sup>2+</sup>]<sub>i</sub>) was tested in rat mesenteric resistance arteries. NPY (100 n M) alone was not able to increase either the contraction or [Ca<sup>2+</sup>]<sub>i</sub>. However, pretreatment of mesenteric resistance arteries with 100 n M NPY potentiated both [Ca<sup>2+</sup>]<sub>i</sub> and active stress induced by 1.5 µ M NA. Addition of 100 n M NPY to vessels that had been precontracted with NA (1.5 µ M) elicited a large increase in [Ca<sup>2+</sup>]<sub>i</sub> and an increase in active stress development. In Ca<sup>2+</sup>-free medium containing 2 m M ethylene glycol-bis(β-aminoethyl ether) NNN’N’-tetraacetic acid, the potentiating effect of NPY on the NA-induced contraction was prevented, and readdition of Ca<sup>2+</sup> resulted in a large increase in both [Ca<sup>2+</sup>]<sub>i</sub> and active stress development. It is concluded that NPY potentiates NA-induced contraction in the isolated mesenteric resistance artery by inducing a rise in [Ca<sup>2+</sup>]<sub>i</sub> through an influx of Ca<sup>2</sup> from the extracellular source.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1993
          1993
          23 September 2008
          : 30
          : 6
          : 309-314
          Affiliations
          aLaboratoire de Pharmacologie Cellulaire et Moléculaire, Université Louis-Pasteur de Strasbourg, Faculté de Pharmacie, Illkirch, France; bDepartment of Internal Medicine, University of Texas Medical Branch at Galveston, Galveston, Tex., USA
          Article
          159011 J Vasc Res 1993;30:309–314
          10.1159/000159011
          8241363
          5ba5ec4c-9465-4870-8b5e-e9396847d939
          © 1993 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 16 April 1993
          : 04 August 1993
          Page count
          Pages: 6
          Categories
          Research Paper

          General medicine,Neurology,Cardiovascular Medicine,Internal medicine,Nephrology
          α-Adrenoceptor,Neuropeptide Y,Intracellular calcium,Rat resistance arteries,Vasoconstriction

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