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Interleukin 7 is produced by murine and human keratinocytes

The Journal of Experimental Medicine

The Rockefeller University Press

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      Abstract

      Interleukin 7 (IL-7) was originally identified as a growth factor for B cell progenitors, and subsequently has been shown to exert proliferative effects on T cell progenitors and mature peripheral T cells as well. Constitutive IL-7 mRNA expression so far had been demonstrated in bone marrow stromal cell lines, thymus, spleen, and among nonlymphoid tissues in liver and kidney. Here we show that both murine and human keratinocytes express IL-7 mRNA and release IL-7 protein in biologically relevant amounts. The physiological or pathological relevance of keratinocyte-derived IL-7 is presently unknown. Our finding that keratinocytes can produce IL-7 in concert with reports that IL-7 is a growth factor for in vivo primed antigen- specific T cells, as well as for T lymphoma cells suggests, however, that keratinocyte-derived IL-7 is important in the pathogenesis of inflammatory skin diseases and cutaneous T cell lymphoma.

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      Author and article information

      Journal
      J Exp Med
      The Journal of Experimental Medicine
      The Rockefeller University Press
      0022-1007
      1540-9538
      1 September 1993
      : 178
      : 3
      : 1109-1114
      2191157
      93353128
      8350050
      Categories
      Articles

      Medicine

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