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      The GDNF family: signalling, biological functions and therapeutic value.

      Nature reviews. Neuroscience

      physiology, Signal Transduction, chemistry, Receptor Protein-Tyrosine Kinases, Proto-Oncogene Proteins c-ret, Proto-Oncogene Proteins, metabolism, Neurons, therapeutic use, Nerve Tissue Proteins, Nerve Growth Factors, Humans, Glial Cell Line-Derived Neurotrophic Factor Receptors, Glial Cell Line-Derived Neurotrophic Factor, Drosophila Proteins, Animals

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          Abstract

          Members of the nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF) families comprising neurotrophins and GDNF-family ligands (GFLs), respectively are crucial for the development and maintenance of distinct sets of central and peripheral neurons. Knockout studies in the mouse have revealed that members of these two families might collaborate or act sequentially in a given neuron. Although neurotrophins and GFLs activate common intracellular signalling pathways through their receptor tyrosine kinases, several clear differences exist between these families of trophic factors.

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          Journal
          11988777
          10.1038/nrn812

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