Sarcoma de Kaposi em paciente transplantada renal em uso de Fk-506 <span class="so-article-trans-title" dir="auto"> Translated title: Kaposi&apos;s Sarcoma in a renal transplant patient receiving Fk-506 </span>

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

O Sarcoma de Kaposi (SK) é neoplasia maligna multicêntrica, cutânea e extracutânea, que tem sido descrita em pacientes transplantados renais que recebem terapia imunossupressora clássica. Este estudo descreve um caso de sarcoma de Kaposi em paciente transplantada renal recebendo FK-506, que surgiu 10 meses após o transplante.

Translated abstract

Kaposi's sarcoma is a cutaneous and extra cutaneous multicentric malignancy that has been widely described in renal-transplant patients under classic immunosuppressive therapy. This study describes a renal-transplant patient under immunosuppressive therapy with FK-506 who presented Kaposi's sarcoma 10 months after the transplantation.

Related collections

Most cited references 8

Record: found
Abstract: found
Article: not found

Transmission of human herpesvirus 8 infection from renal-transplant donors to recipients.

N Regamey, M Wernli, G Cathomas … (1998)

Human herpesvirus 8 (HHV-8) has been detected in all forms of Kaposi's sarcoma, including transplantation-associated Kaposi's sarcoma. To investigate the possibility of transmission of HHV-8 through allografts, we measured the seroprevalence of HHV-8 before and after renal transplantation. Using an enzyme-linked immunosorbent assay with the recombinant HHV-8 protein orf 65.2, we analyzed serum samples from 220 renal-transplant recipients for the presence of antibodies to HHV-8 on the day of transplantation and one year later. Positive results were confirmed by an indirect immunofluorescence assay that detects antibodies to latent antigen and by Western blotting. Follow-up lasted at least four years. The seroprevalence of HHV-8 in graft recipients increased from 6.4 percent on the day of transplantation to 17.7 percent one year after transplantation. Seroconversion occurred within the first year after transplantation in 25 patients, and Kaposi's sarcoma developed in 2 of them within 26 months after transplantation. Sequential serum samples were obtained from 10 of the patients with seroconversion, and in 8 of these patients, IgM antibodies to HHV-8 appeared within three months after transplantation. In the case of six patients who seroconverted, serum samples from the donors were available, and five (83 percent) tested positive for HHV-8. In a control group of eight patients who were seronegative at the time of transplantation and who received allografts from HHV-8-negative donors, none seroconverted within the year after transplantation. HHV-8 is transmitted through renal allografts and is a risk factor for transplantation-associated Kaposi's sarcoma.

0 comments Cited 35 times – based on 0 reviews      Review now

Record: found
Abstract: not found
Article: not found

Discovery of FK-506, a novel immunosuppressant isolated from Streptomyces tsukubaensis.

H. Aoki, T. Goto, H Imanaka … (1987)

0 comments Cited 18 times – based on 0 reviews      Review now

Record: found
Abstract: found
Article: not found

Viral infections after renal transplantation.

Stephen Smith, David W Butterly, Barbara D. Alexander … (2001)

Viral infections are a leading cause of posttransplantation morbidity and mortality. A number of recent developments have altered our understanding and management of these disorders. The pathogenetic roles of several viruses, including human herpesviruses 6 and 8, have been newly established. Molecular-based diagnostic tests now make more rapid diagnosis possible. The licensing of new potent antiviral agents offers a wider choice of drugs for viral prophylaxis and treatment. The use of more potent immunosuppressive agents is responsible in part for the increasing incidence of some viral infections, but this varies among drugs, and individual viruses differ in their sensitivity to immunosuppressive agents. This review summarizes the natural history, diagnosis, prevention, and treatment of many common viral infections after renal transplantation.

0 comments Cited 16 times – based on 0 reviews      Review now

All references

Author and article information

Journal

Journal ID (publisher-id): abd

Title: Anais Brasileiros de Dermatologia

Abbreviated Title: An. Bras. Dermatol.

Publisher: Sociedade Brasileira de Dermatologia (Rio de Janeiro, RJ, Brazil )

ISSN (Print): 0365-0596

ISSN (Electronic): 1806-4841

Publication date (Print and electronic): December 2002

Volume: 77

Issue: 6

Pages: 707-710

Affiliations

[01] Porto Alegre Rio Grande do Sul orgnameComplexo Hospitalar Santa Casa orgdiv1Serviço de Dermatologia da UFRGS Brasil

Article

Publisher ID: S0365-05962002000600008 Publisher ID: S0365-0596(02)07700608

SO-VID: 5bc765ff-d4a9-468c-8e11-efaa6a6d6d55

License:

This work is licensed under a Creative Commons Attribution 4.0 International License.

History

Date received : 08 June 2001

Date accepted : 23 March 2002

Page count

Figures: 0, Tables: 0, Equations: 0, References: 8, Pages: 4

Product

SciELO Brazil

Sarcoma de Kaposi em paciente transplantada renal em uso de Fk-506 Translated title: Kaposi's Sarcoma in a renal transplant patient receiving Fk-506

Read this article at