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      Prevention of Chloroquine-lnduced Electroretinographic Damage by a New Platelet-Activating Factor Antagonist, BN 50730

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          Chloroquine retinopathy is a severe toxic retinal impairment which may result in loss of vision by alterations of the retinal pigment epithelium and photoreceptors. Currently, there is no specific treatment for this retinopathy. Platelet-activating factor (PAF) is known to modulate retinal function and is one of the major immunomediators of the retina. In order to test the possible involvement of PAF in chloroquine-induced retinopathy and the effectiveness of PAF antagonists in the prevention of this condition, we investigated the effects of BN 50730, a specific PAF antagonist, on the electroretinogram (ERG) of the isolated rat retina exposed to chloroquine. When retinas from normal rats were perfused with chloroquine (10<sup>-6</sup> M), a marked and rapid decrease in b-wave amplitude was observed. In contrast, chloroquine had no effect on the b-wave of the retina isolated from animals pretreated with the PAF antagonist BN 50730 (30 mg/kg/day, i.p., for 5 days). The results obtained indicate that (i) chloroquine is a toxic drug for retinal function, (ii) PAF plays a key role in the mediation of chloroquine retinopathy and (iii) PAF antagonists may constitute valuable agents for the treatment of this retinal impairment.

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          11 December 2009
          : 25
          : 5
          : 314-318
          aLaboratoire de Biophysique, INSERM U71, Facultés de Médecine et de Pharmacie, Clermont-Ferrand, France; bInstitut Henri-Beaufour (IHB) Research Laboratories, Le Plessis-Robinson, France
          267331 Ophthalmic Res 1993;25:314–318
          © 1993 S. Karger AG, Basel

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          Pages: 5
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