A combined administration of Aragvādādi kaṣāyam and Syrup Talekt induced skin rashes

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Abstract

It is a common notion among people in India that herbal or Ayurvedic products are safe and do not produce any adverse effect. This is not true since Ayurveda has evaded many adverse effects which occur by combination of herbs. This axiom is potentiated by our report that occurs in the form of skin rashes. A 20-year-old South Indian female of Pittakapha prakṛti (constitution) after beginning therapy with Aragvādādi kaṣāyam (ARK) (poly-herbal formulation) and Syrup Talekt (poly-herbal patent formulation) for the treatment of recurrent incidence of abscess. Rash disappeared after stopping the suspected drug and treatment with Vibhītakī kaṣāyam (decoction of Terminilia bellarica) and Śatadhauta ghṛtam. Possible and probable (score 6) were the causality according to WHO-Uppsala Monitoring Centre and Naranjo's Adverse Drug Reaction Probability Scale and grouped under type-B reaction. To the best of our knowledge, this is the first case of skin rashes which seen after administration of ARK and Syrup Talekt. This report highlights the need of implementation of pharmacovigilance center in the hospital level and additional research in the field of skin toxicity of ARK and Syrup Talekt.

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Most cited references 14

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ADVERSE CUTANEOUS DRUG REACTION

Surajit Nayak, Basanti Acharjya (2008)

In everyday clinical practice, almost all physicians come across many instances of suspected adverse cutaneous drug reactions (ACDR) in different forms. Although such cutaneous reactions are common, comprehensive information regarding their incidence, severity and ultimate health effects are often not available as many cases go unreported. It is also a fact that in the present world, almost everyday a new drug enters market; therefore, a chance of a new drug reaction manifesting somewhere in some form in any corner of world is unknown or unreported. Although many a times, presentation is too trivial and benign, the early identification of the condition and identifying the culprit drug and omit it at earliest holds the keystone in management and prevention of a more severe drug rash. Therefore, not only the dermatologists, but all practicing physicians should be familiar with these conditions to diagnose them early and to be prepared to handle them adequately. However, we all know it is most challenging and practically difficult when patient is on multiple medicines because of myriad clinical symptoms, poorly understood multiple mechanisms of drug-host interaction, relative paucity of laboratory testing that is available for any definitive and confirmatory drug-specific testing. Therefore, in practice, the diagnosis of ACDR is purely based on clinical judgment. In this discussion, we will be primarily focusing on pathomechanism and approach to reach a diagnosis, which is the vital pillar to manage any case of ACDR.

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Antibiotic rashes in children: a survey in a private practice setting.

Bernhard L Wiedermann, E O Ibia, Allison R. Schwartz (2000)

To document the frequency and severity of various types of rashes seen with commonly used oral antibiotics in the pediatric outpatient setting. A retrospective review of 5923 patient records at a pediatric office. A private group pediatric practice in northern Virginia with about 12,000 registered active patients. Approximately 50% of the clinic medical records were reviewed. All children (defined as those aged 0-18 years in this study) identified on their medical records as having developed a rash following treatment with 1 or more of the commonly used oral antibiotics were included in the study. For further validation, a questionnaire about parental recollection of description of rash, other associated symptoms, physician verification, and outcome was mailed to families with children designated as being allergic to an antibiotic. On a prescription basis, significantly more rashes were documented for cefaclor (4.79%) compared with penicillins (2.72%), sulfonamides (3. 46%), and other cephalosporins (1.04%). Based on the number of patients for whom each group of antibiotic was prescribed, the documented frequencies of rashes were 12.3%, 7.4%, 8.5%, and 2.6% for cefaclor, penicillins, sulfonamides, and other cephalosporins, respectively. None of the children had rashes severe enough to require hospitalization. In a review of almost 6000 records in a private pediatric primary care setting, rashes occurred in 7.3% of children who were given the commonly used oral antibiotics. Significantly more rashes were documented with cefaclor use than with use of any of the other oral antibiotics.

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Subacute thyroiditis following ginger (Zingiber officinale) consumption

Suzan Sanavi, Reza Karbasi-Afshar (2010)

A woman with subacute thyroiditis following ginger consumption is presented. The diagnosis was confirmed by physical examination and laboratory tests, in two distinct episodes. The patient was cured and recommended to refuse ginger consumption.

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Author and article information

Journal

Journal ID (nlm-ta): Anc Sci Life

Journal ID (iso-abbrev): Anc Sci Life

Journal ID (publisher-id): ASL

Title: Ancient Science of Life

Publisher: Medknow Publications & Media Pvt Ltd (India )

ISSN (Print): 0257-7941

ISSN (Electronic): 2249-9547

Publication date (Print): Jan-Mar 2014

Volume: 33

Issue: 3

Pages: 172-175

Affiliations

[1]Department of Dravyaguna and Medical Research Center, Rajiv Gandhi Education Society's Ayurveda Medical College and PG Research Centre, Ron, India

[1 ]Department of Panchakarma, KLEU Shri BMK Ayurved Mahavidhyalaya, Belgaum, Karnataka, India

Author notes

Address for correspondence: Dr. Manjunath Ajanal, Research Officer cum Assistant Professor Department of Dravyaguna and Medical Research Center Rajiv Gandhi Education Society's Ayurveda Medical College and PG Research Centre, Ron - 582 209, Karnataka, India. E-mail: manju.ajanal@ 123456gmail.com

Article

Publisher ID: ASL-33-172

DOI: 10.4103/0257-7941.144622

PMC ID: 4264306

SO-VID: 5bd656ff-8b7e-410c-81d7-32cd0dce9b4d

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This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

A combined administration of Aragvādādi kaṣāyam and Syrup Talekt induced skin rashes

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China Tropical Medicine

Most cited references 14

ADVERSE CUTANEOUS DRUG REACTION

Antibiotic rashes in children: a survey in a private practice setting.

Subacute thyroiditis following ginger (Zingiber officinale) consumption

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