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      Pathoblockers or antivirulence drugs as a new option for the treatment of bacterial infections

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          Abstract

          The rapid development of antimicrobial resistance is threatening mankind to such an extent that the World Health Organization expects more deaths from infections than from cancer in 2050 if current trends continue. To avoid this scenario, new classes of anti-infectives must urgently be developed. Antibiotics with new modes of action are needed, but other concepts are also currently being pursued. Targeting bacterial virulence as a means of blocking pathogenicity is a promising new strategy for disarming pathogens. Furthermore, it is believed that this new approach is less susceptible towards resistance development. In this review, recent examples of anti-infective compounds acting on several types of bacterial targets, e.g., adhesins, toxins and bacterial communication, are described.

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          Carbohydrate-based anti-virulence compounds against chronic Pseudomonas aeruginosa Infections with a focus on small molecules

          A. Titz (2014)
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            Author and article information

            Contributors
            Role: Guest Editor
            Journal
            Beilstein J Org Chem
            Beilstein J Org Chem
            Beilstein Journal of Organic Chemistry
            Beilstein-Institut (Trakehner Str. 7-9, 60487 Frankfurt am Main, Germany )
            1860-5397
            2018
            11 October 2018
            : 14
            : 2607-2617
            Affiliations
            [1 ]Chemical Biology of Carbohydrates, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), D-66123 Saarbrücken, Germany
            [2 ]Deutsches Zentrum für Infektionsforschung (DZIF), Standort Hannover-Braunschweig, Germany
            [3 ]Department of Pharmacy, Saarland University, Saarbrücken, Germany
            Article
            10.3762/bjoc.14.239
            6204809
            5bdd4d90-39c8-4451-84ad-fc81d7bf5b42
            Copyright © 2018, Calvert et al.; licensee Beilstein-Institut.

            This is an Open Access article under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the authors and source are credited.

            The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc)

            Categories
            Review
            Chemistry
            Organic Chemistry

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