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      Residential green space in childhood is associated with lower risk of psychiatric disorders from adolescence into adulthood

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          Growing up in urban environments is associated with risk of developing psychiatric disorders, but the underlying mechanisms are unknown. Green space can provide mental health benefits and possibly lower risk of psychiatric disorders. This nation-wide study covering >900,000 people shows that children who grew up with the lowest levels of green space had up to 55% higher risk of developing a psychiatric disorder independent from effects of other known risk factors. Stronger association between cumulated green space and risk during childhood constitutes evidence that prolonged presence of green space is important. Our findings affirm that integrating natural environments into urban planning is a promising approach to improve mental health and reduce the rising global burden of psychiatric disorders.

          Abstract

          Urban residence is associated with a higher risk of some psychiatric disorders, but the underlying drivers remain unknown. There is increasing evidence that the level of exposure to natural environments impacts mental health, but few large-scale epidemiological studies have assessed the general existence and importance of such associations. Here, we investigate the prospective association between green space and mental health in the Danish population. Green space presence was assessed at the individual level using high-resolution satellite data to calculate the normalized difference vegetation index within a 210 × 210 m square around each person’s place of residence (∼1 million people) from birth to the age of 10. We show that high levels of green space presence during childhood are associated with lower risk of a wide spectrum of psychiatric disorders later in life. Risk for subsequent mental illness for those who lived with the lowest level of green space during childhood was up to 55% higher across various disorders compared with those who lived with the highest level of green space. The association remained even after adjusting for urbanization, socioeconomic factors, parental history of mental illness, and parental age. Stronger association of cumulative green space presence during childhood compared with single-year green space presence suggests that presence throughout childhood is important. Our results show that green space during childhood is associated with better mental health, supporting efforts to better integrate natural environments into urban planning and childhood life.

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          Most cited references31

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          A Review of the Health Benefits of Greenness.

          Researchers are increasingly exploring how neighborhood greenness, or vegetation, may affect health behaviors and outcomes. Greenness may influence health by promoting physical activity and social contact; decreasing stress; and mitigating air pollution, noise, and heat exposure. Greenness is generally measured using satellite-based vegetation indices or land-use databases linked to participants' addresses. In this review, we found fairly strong evidence for a positive association between greenness and physical activity, and a less consistent negative association between greenness and body weight. Research suggests greenness is protective against adverse mental health outcomes, cardiovascular disease, and mortality, though most studies were limited by cross-sectional or ecological design. There is consistent evidence that greenness exposure during pregnancy is positively associated with birth weight, though findings for other birth outcomes are less conclusive. Future research should follow subjects prospectively, differentiate between greenness quantity and quality, and identify mediators and effect modifiers of greenness-health associations.
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            Green spaces and cognitive development in primary schoolchildren.

            Exposure to green space has been associated with better physical and mental health. Although this exposure could also influence cognitive development in children, available epidemiological evidence on such an impact is scarce. This study aimed to assess the association between exposure to green space and measures of cognitive development in primary schoolchildren. This study was based on 2,593 schoolchildren in the second to fourth grades (7-10 y) of 36 primary schools in Barcelona, Spain (2012-2013). Cognitive development was assessed as 12-mo change in developmental trajectory of working memory, superior working memory, and inattentiveness by using four repeated (every 3 mo) computerized cognitive tests for each outcome. We assessed exposure to green space by characterizing outdoor surrounding greenness at home and school and during commuting by using high-resolution (5 m × 5 m) satellite data on greenness (normalized difference vegetation index). Multilevel modeling was used to estimate the associations between green spaces and cognitive development. We observed an enhanced 12-mo progress in working memory and superior working memory and a greater 12-mo reduction in inattentiveness associated with greenness within and surrounding school boundaries and with total surrounding greenness index (including greenness surrounding home, commuting route, and school). Adding a traffic-related air pollutant (elemental carbon) to models explained 20-65% of our estimated associations between school greenness and 12-mo cognitive development. Our study showed a beneficial association between exposure to green space and cognitive development among schoolchildren that was partly mediated by reduction in exposure to air pollution.
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              Regulation of the immune system by biodiversity from the natural environment: An ecosystem service essential to health

              Epidemiological studies suggest that living close to the natural environment is associated with long-term health benefits including reduced death rates, reduced cardiovascular disease, and reduced psychiatric problems. This is often attributed to psychological mechanisms, boosted by exercise, social interactions, and sunlight. Compared with urban environments, exposure to green spaces does indeed trigger rapid psychological, physiological, and endocrinological effects. However, there is little evidence that these rapid transient effects cause long-term health benefits or even that they are a specific property of natural environments. Meanwhile, the illnesses that are increasing in high-income countries are associated with failing immunoregulation and poorly regulated inflammatory responses, manifested as chronically raised C-reactive protein and proinflammatory cytokines. This failure of immunoregulation is partly attributable to a lack of exposure to organisms (“Old Friends”) from mankind’s evolutionary past that needed to be tolerated and therefore evolved roles in driving immunoregulatory mechanisms. Some Old Friends (such as helminths and infections picked up at birth that established carrier states) are almost eliminated from the urban environment. This increases our dependence on Old Friends derived from our mothers, other people, animals, and the environment. It is suggested that the requirement for microbial input from the environment to drive immunoregulation is a major component of the beneficial effect of green space, and a neglected ecosystem service that is essential for our well-being. This insight will allow green spaces to be designed to optimize health benefits and will provide impetus from health systems for the preservation of ecosystem biodiversity.
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                Author and article information

                Journal
                Proc Natl Acad Sci U S A
                Proc. Natl. Acad. Sci. U.S.A
                pnas
                pnas
                PNAS
                Proceedings of the National Academy of Sciences of the United States of America
                National Academy of Sciences
                0027-8424
                1091-6490
                12 March 2019
                25 February 2019
                25 February 2019
                : 116
                : 11
                : 5188-5193
                Affiliations
                [1] aSection for Ecoinformatics & Biodiversity, Department of Bioscience, Aarhus University , 8000 Aarhus C, Denmark;
                [2] bCenter for Biodiversity Dynamics in a Changing World, Department of Bioscience, Aarhus University , 8000 Aarhus C, Denmark;
                [3] cCentre for Integrated Register-based Research, Aarhus University , 8210 Aarhus V, Denmark;
                [4] dNational Centre for Register-based Research, School of Business and Social Sciences, Department of Economics and Business Economics, Aarhus University , 8210 Aarhus V, Denmark;
                [5] eThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus University , 8210 Aarhus V, Denmark;
                [6] fCenter for Massive Data Algorithmics, Department of Computer Science, Aarhus University , 8200 Aarhus N, Denmark
                Author notes
                1To whom correspondence should be addressed. Email: engemann@ 123456bios.au.dk .

                Edited by Terry Hartig, Uppsala University, Uppsala, Sweden, and accepted by Editorial Board Member Susan T. Fiske January 14, 2019 (received for review May 2, 2018)

                Author contributions: K.E., C.B.P., P.B.M., and J.-C.S. designed research; K.E. performed research; L.A. and C.T. contributed new reagents/analytic tools; K.E. analyzed data; and K.E., C.B.P., P.B.M., and J.-C.S. wrote the paper.

                Author information
                http://orcid.org/0000-0003-1431-1726
                Article
                201807504
                10.1073/pnas.1807504116
                6421415
                30804178
                5bde3eb9-8fe6-4459-8ad5-7ade9392b7ab
                Copyright © 2019 the Author(s). Published by PNAS.

                This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

                History
                Page count
                Pages: 6
                Funding
                Funded by: Villum Fonden (Villum Foundation) 100008398
                Award ID: 16549
                Award Recipient : Jens-Christian Svenning
                Categories
                9
                Biological Sciences
                Sustainability Science
                Social Sciences
                Environmental Sciences

                geographic information systems,mental health,psychological ecosystem services,remote sensing,urban planning

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