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      Aerobic exercise prescription in heart failure patients with cardiac resynchronization therapy

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          Abstract

          Exercise for heart failure patients had been shown to be beneficial in improving functional status, and was reviewed to be safe. In cases of advanced heart failure, Cardiac Resynchronization Therapy (CRT) is a promising medical option before being a heart transplant candidate. CRT itself is a biventricular pacing device, which could detect electrical aberrance in the failing heart and provide a suitable response. Studies have shown that exercise has clear benefits toward improving an overall exercise capacity of the patients. Despite its impacts, these randomized clinical trials have varying exercise regime, and until now there has not been a standardized exercise prescription for this group of patients. The nature of CRT as a pacemaker, sometimes with defibrillator, being attached to a heart failure patient, each has its own potential exercise hazards. Therefore, providing detailed exercise prescription in adjusting to the medical condition is very essential in the field of physical medicine and rehabilitation. Being classified as a high‐risk patient group, exercise challenges for the complex heart failure with CRT patients will then be discussed in this literature review, with a general aim to provide a safe, effective, and targeted exercise regime.

          Abstract

          It is not uncommon to face heart failure patients with cardiac resynchronization device in our daily practice. Regardless of their poor physiologic function, the main challenge is to achieve the highest possible functional outcome of this special population. Therefore, our review discussed the highlights of exercise prescription, without disregarding its safety and limitations.

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          Most cited references51

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          ATS statement: guidelines for the six-minute walk test.

          (2002)
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            Exercise standards for testing and training: a scientific statement from the American Heart Association.

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              Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial.

              Guidelines recommend that exercise training be considered for medically stable outpatients with heart failure. Previous studies have not had adequate statistical power to measure the effects of exercise training on clinical outcomes. To test the efficacy and safety of exercise training among patients with heart failure. Multicenter, randomized controlled trial of 2331 medically stable outpatients with heart failure and reduced ejection fraction. Participants in Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION) were randomized from April 2003 through February 2007 at 82 centers within the United States, Canada, and France; median follow-up was 30 months. Usual care plus aerobic exercise training, consisting of 36 supervised sessions followed by home-based training, or usual care alone. Composite primary end point of all-cause mortality or hospitalization and prespecified secondary end points of all-cause mortality, cardiovascular mortality or cardiovascular hospitalization, and cardiovascular mortality or heart failure hospitalization. The median age was 59 years, 28% were women, and 37% had New York Heart Association class III or IV symptoms. Heart failure etiology was ischemic in 51%, and median left ventricular ejection fraction was 25%. Exercise adherence decreased from a median of 95 minutes per week during months 4 through 6 of follow-up to 74 minutes per week during months 10 through 12. A total of 759 patients (65%) in the exercise training group died or were hospitalized compared with 796 patients (68%) in the usual care group (hazard ratio [HR], 0.93 [95% confidence interval {CI}, 0.84-1.02]; P = .13). There were nonsignificant reductions in the exercise training group for mortality (189 patients [16%] in the exercise training group vs 198 patients [17%] in the usual care group; HR, 0.96 [95% CI, 0.79-1.17]; P = .70), cardiovascular mortality or cardiovascular hospitalization (632 [55%] in the exercise training group vs 677 [58%] in the usual care group; HR, 0.92 [95% CI, 0.83-1.03]; P = .14), and cardiovascular mortality or heart failure hospitalization (344 [30%] in the exercise training group vs 393 [34%] in the usual care group; HR, 0.87 [95% CI, 0.75-1.00]; P = .06). In prespecified supplementary analyses adjusting for highly prognostic baseline characteristics, the HRs were 0.89 (95% CI, 0.81-0.99; P = .03) for all-cause mortality or hospitalization, 0.91 (95% CI, 0.82-1.01; P = .09) for cardiovascular mortality or cardiovascular hospitalization, and 0.85 (95% CI, 0.74-0.99; P = .03) for cardiovascular mortality or heart failure hospitalization. Other adverse events were similar between the groups. In the protocol-specified primary analysis, exercise training resulted in nonsignificant reductions in the primary end point of all-cause mortality or hospitalization and in key secondary clinical end points. After adjustment for highly prognostic predictors of the primary end point, exercise training was associated with modest significant reductions for both all-cause mortality or hospitalization and cardiovascular mortality or heart failure hospitalization. clinicaltrials.gov Identifier: NCT00047437.
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                Author and article information

                Contributors
                kevintriangto14@gmail.com
                Journal
                J Arrhythm
                J Arrhythm
                10.1002/(ISSN)1883-2148
                JOA3
                Journal of Arrhythmia
                John Wiley and Sons Inc. (Hoboken )
                1880-4276
                1883-2148
                09 December 2020
                February 2021
                : 37
                : 1 ( doiID: 10.1002/joa3.v37.1 )
                : 165-172
                Affiliations
                [ 1 ] Department of Physical Medicine and Rehabilitation Faculty of Medicine Universitas Indonesia Jakarta Indonesia
                [ 2 ] Department of Cardiology and Vascular Medicine Faculty of Medicine Universitas Indonesia Jakarta Indonesia
                Author notes
                [*] [* ] Correspondence

                Kevin Triangto, Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Universitas Indonesia, Jl. Diponegoro No. 71, Jakarta 10430, Indonesia.

                Email: kevintriangto14@ 123456gmail.com

                Author information
                https://orcid.org/0000-0003-1582-7142
                https://orcid.org/0000-0003-3239-3542
                https://orcid.org/0000-0002-6428-9304
                Article
                JOA312475
                10.1002/joa3.12475
                7896451
                5be95868-fc09-4ec3-b025-c9adccd6ff3d
                © 2020 The Authors. Journal of Arrhythmia published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Heart Rhythm Society.

                This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

                History
                : 25 June 2020
                : 09 November 2020
                : 18 November 2020
                Page count
                Figures: 1, Tables: 3, Pages: 8, Words: 7508
                Categories
                Clinical Review
                Clinical Review
                Custom metadata
                2.0
                February 2021
                Converter:WILEY_ML3GV2_TO_JATSPMC version:5.9.7 mode:remove_FC converted:20.02.2021

                aerobic exercise prescription,cardiac resynchronization therapy,functional capacity,heart failure,rehabilitation

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