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      Hypothalamic Sarcoidosis and Hypopituitarism

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          4 patients with presumed pituitary hypothalamic sarcoidosis are described. 3 had histological diagnoses compatible with sarcoidosis and in the other this diagnosis was strongly suspected from chest X-rays. 2 patients presented with diabetes insipidus. ACTH reserve was diminished in 3 out of 4 and growth hormone reserve was diminished in the 3 who were tested. All 4 patients developed secondary amenorrhea. 3 patients had hypothalamic hypothyroidism. Prolactin dynamics were intact. Tomograms of the sella turcica in all 4 and computerized tomography of the hypothalamic area in 2 patients failed to reveal any abnormality.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          25 November 2008
          : 12
          : 1
          : 1-9
          Division of Endocrinology, Department of Internal Medicine, University of Colorado Medical Center, Denver, Colo.
          179099 Horm Res 1980;12:1–9
          © 1980 S. Karger AG, Basel

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          Pages: 9
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