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      Inflammation and metabolic disorders.

      Nature

      Adipose Tissue, immunology, pathology, Animals, Diabetes Mellitus, Type 2, complications, metabolism, Humans, Inflammation, drug therapy, Insulin Resistance, Metabolic Syndrome X, Obesity

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          Abstract

          Metabolic and immune systems are among the most fundamental requirements for survival. Many metabolic and immune response pathways or nutrient- and pathogen-sensing systems have been evolutionarily conserved throughout species. As a result, immune response and metabolic regulation are highly integrated and the proper function of each is dependent on the other. This interface can be viewed as a central homeostatic mechanism, dysfunction of which can lead to a cluster of chronic metabolic disorders, particularly obesity, type 2 diabetes and cardiovascular disease. Collectively, these diseases constitute the greatest current threat to global human health and welfare.

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          Author and article information

          Journal
          17167474
          10.1038/nature05485

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