Patterns of α-Adrenoceptor Regulation of the Vasculature

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

There are patterns in the distribution of the characteristics of vascular α-adrenoceptors. Sudden changes in their mechanism occur at particular sites along the main branches of the aorta; in some regional vascular beds, but not others, there is a progressive reduction in the response that can be elicited through the α-adrenoceptor; in smaller blood vessels, α- and β-adrenoceptors may be spatially separated in the vessel wall; in most blood vessels, the inner smooth muscle is more sensitive to α-agonists and more dependent on sequestered calcium than the outer. There is little support for a significant physiological role of the proposed γ-receptor.

Related collections

Author and article information

Journal

Journal ID (publisher-id): JVR

Journal ID (nlm-ta): J Vasc Res

Journal ID (doi): 10.1159/issn.1018-1172

Title: Journal of Vascular Research

Publisher: S. Karger AG

ISBN: 978-3-8055-3927-2

ISBN: 978-3-318-00121-1

ISSN (Print): 1018-1172

ISSN (Electronic): 1423-0135

Publication date Subscription-year: 1984

Publication date (Print): 1984

Publication date (Electronic): 23 September 2008

Volume: 21

Issue: 3

Pages: 110-116

Affiliations

College of Medicine, Given Building, University of Vermont, Burlington, Vt., USA

Article

Publisher ID: 158503 Other ID: Blood Vessels 1984;21:110–116

DOI: 10.1159/000158503

SO-VID: 5c14c5d9-0d36-4c33-9df9-3423adb20b66

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Patterns of α-Adrenoceptor Regulation of the Vasculature

Read this article at

Abstract

Related collections

Karger: Cardiovascular System

Author and article information

Journal

Affiliations

Article

History

Page count

Categories

Comments

Comment on this article

Similar content 137