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      Serum Levels of Prolactin, LH and LH-RH after Ablation of the Medial Basal Hypothalamus

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      Hormone Research in Paediatrics

      S. Karger AG

      Medial hypothalamic ablation, Prolactin, LH, LH-RH, Ether stress

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          4 weeks after surgical ablation (MHA) of the medial basal hypothalamus (MBH) in adult male rats, serum levels of prolactin, LH, and LH-RH were determined by radioimmunoassay. Blood samples were obtained by jugular venipuncture under ether anesthesia (designated ‘stress’ samples) and 30 min after the ether stress by rapid decapitation (designated ‘resting’ samples). 30 min after ether, serum levels of prolactin, LH, and LH-RH in MHA rats were comparable to those of intact and sham-operated controls. Among intact and sham-operated rats, ether elicited an initial increase in prolactin but not in LH or LH-RH. In the MHA group, prolactin levels were also acutely increased, although the increment was not as great as in control groups. The data indicate that considerable basal prolactin and LH secretion persists after MHA, and that this continued secretion may be regulated by neurohormones such as LH-RH which arise from areas outside the MBH.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          25 November 2008
          : 9
          : 2
          : 73-82
          Department of Anatomy, University of Rochester, School of Medicine and Dentistry, Rochester, N.Y.
          178898 Horm Res 1978;9:73–82
          © 1978 S. Karger AG, Basel

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          Pages: 10
          Original Paper


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