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      Free radicals and disease.

      1 , ,
      Archives of biochemistry and biophysics
      Elsevier BV

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          Abstract

          Free radicals and reactive oxygen species (ROS) have been associated with the etiology and/or progression of a number of diseases and in aging. Many of the proteins oxidatively modified by free radicals contain side-chain carbonyl derivatives, which can be used as markers for protein oxidation. The protein carbonyl content has been quantitated as a function of age for human cultured dermal fibroblasts, lens, and brain tissue. These data were analyzed using a simple autocatalytic model with the assumption that free radicals randomly oxidize proteins or peptides to form carbonyl derivatives and lead to their inactivation. The carbonylated proteins and peptides are highly susceptible to proteolytic degradation. Implication of free radicals in aging and in age-dependent susceptibility to neurodegenerative diseases will be discussed in light of this simplified kinetic model.

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          Author and article information

          Journal
          Arch Biochem Biophys
          Archives of biochemistry and biophysics
          Elsevier BV
          0003-9861
          0003-9861
          Jan 15 2002
          : 397
          : 2
          Affiliations
          [1 ] Laboratory of Biochemistry, National Heart, Lung and Blood Institute, NIH, Bethesda, Maryland 20892-8012, USA.
          Article
          S000398610192692X
          10.1006/abbi.2001.2692
          11795894
          5c4c4c39-a482-4eef-bb11-dc2a284b5b8d
          (c)2002 Elsevier Science.
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