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      Análisis de la fragilidad y su relación con la calidad de vida en pacientes con enfermedad renal crónica avanzada Translated title: Analysis of frailty and its relationship with quality of life in patients with advanced chronic kidney disease

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          Abstract

          RESUMEN Introducción: La enfermedad renal crónica avanzada afecta principalmente a pacientes mayores de 65 años, con cierto grado de fragilidad y dependencia, lo que unido a la alta comorbilidad afecta en gran medida a la calidad de vida de estas personas. Objetivos: Valorar la fragilidad en pacientes con enfermedad renal crónica avanzada y su efecto sobre la calidad de vida, así como su relación con la dependencia. Material y Método: Se estudiaron 107 pacientes, con una mediana de edad de 74 años (RI=18); 37 mujeres (34,6%). Se realizó un estudio descriptivo de corte trasversal en la consulta de enfermedad renal crónica avanzada del Servicio de Nefrología del Hospital Universitario Reina Sofía de Córdoba. Se incluyeron pacientes en estadíos 4-5 sin tratamiento renal sustitutivo previo. Se emplearon los cuestionarios: FRAIL para evaluar la fragilidad; KDQOL-SF, para la valoración de la calidad de vida relacionada con la salud; y el test de Barthel para establecer el grado de dependencia. Resultados: El 61,3% de los pacientes presentó algún grado de fragilidad y un 26,2% afectación para realizar alguna actividad básica de la vida diaria. La fragilidad se asoció con peor calidad de vida, estando afectadas la mayoría de dimensiones del cuestionario KDQOL-SF, y con dependencia. Las dimensiones del KDQOL-SF más afectadas fueron Situación laboral y Sueño del cuestionario específico y Salud general y Vitalidad del cuestionario genérico. Conclusiones: La fragilidad está presente de forma importante en los pacientes con enfermedad renal crónica avanzada asociándose a peor calidad de vida y mayor grado de dependencia.

          Translated abstract

          ABSTRACT Introduction: Advanced chronic kidney disease primarily affects patients over 65 years old, often with a certain degree of frailty and dependency. This, coupled with high comorbidity, significantly impacts the quality of life for these individuals. Objectives: To assess frailty in patients with advanced chronic kidney disease and its impact on quality of life, as well as its relationship with dependency. Material and Method: A total of 107 patients were studied, with a median age of 74 years (IQR=18); 37 were women (34.6%). A cross-sectional descriptive study was conducted in the advanced chronic kidney disease clinic of the Nephrology Department at Reina Sofía University Hospital in Córdoba. Patients in stages 4-5 without prior renal replacement therapy were included. The following questionnaires were employed: FRAIL to assess frailty; KDQOL-SF for health-related quality of life assessment; and the Barthel Index to establish the degree of dependency. Results: Some degree of frailty was exhibited in 61.3% of patients, and 26.2% of them had difficulty performing some basic activities of daily living. Frailty was associated with a poorer quality of life, with most dimensions of the KDQOL-SF questionnaire affected, and with dependency. The most affected dimensions of the KDQOL-SF were Employment Status and Sleep from the specific questionnaire and General Health and Vitality from the generic questionnaire. Conclusions: Frailty is significantly present in patients with advanced chronic kidney disease, and it is associated with a lower quality of life and a higher degree of dependency.

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          Chronic kidney disease as a global public health problem: approaches and initiatives - a position statement from Kidney Disease Improving Global Outcomes.

          Chronic kidney disease (CKD) is increasingly recognized as a global public health problem. There is now convincing evidence that CKD can be detected using simple laboratory tests, and that treatment can prevent or delay complications of decreased kidney function, slow the progression of kidney disease, and reduce the risk of cardiovascular disease (CVD). Translating these advances to simple and applicable public health measures must be adopted as a goal worldwide. Understanding the relationship between CKD and other chronic diseases is important to developing a public health policy to improve outcomes. The 2004 Kidney Disease Improving Global Outcomes (KDIGO) Controversies Conference on 'Definition and Classification of Chronic Kidney Disease' represented an important endorsement of the Kidney Disease Outcome Quality Initiative definition and classification of CKD by the international community. The 2006 KDIGO Controversies Conference on CKD was convened to consider six major topics: (1) CKD classification, (2) CKD screening and surveillance, (3) public policy for CKD, (4) CVD and CVD risk factors as risk factors for development and progression of CKD, (5) association of CKD with chronic infections, and (6) association of CKD with cancer. This report contains the recommendations from the meeting. It has been reviewed by the conference participants and approved as position statement by the KDIGO Board of Directors. KDIGO will work in collaboration with international and national public health organizations to facilitate implementation of these recommendations.
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            Frailty measurement in research and clinical practice: A review.

            One of the leading causes of morbidity and premature mortality in older people is frailty. Frailty occurs when multiple physiological systems decline, to the extent that an individual's cellular repair mechanisms cannot maintain system homeostasis. This review gives an overview of the definitions and measurement of frailty in research and clinical practice, including: Fried's frailty phenotype; Rockwood and Mitnitski's Frailty Index (FI); the Study of Osteoporotic Fractures (SOF) Index; Edmonton Frailty Scale (EFS); the Fatigue, Resistance, Ambulation, Illness and Loss of weight (FRAIL) Index; Clinical Frailty Scale (CFS); the Multidimensional Prognostic Index (MPI); Tilburg Frailty Indicator (TFI); PRISMA-7; Groningen Frailty Indicator (GFI), Sherbrooke Postal Questionnaire (SPQ); the Gérontopôle Frailty Screening Tool (GFST) and the Kihon Checklist (KCL), among others. We summarise the main strengths and limitations of existing frailty measurements, and examine how well these measurements operationalise frailty according to Clegg's guidelines for frailty classification - that is: their accuracy in identifying frailty; their basis on biological causative theory; and their ability to reliably predict patient outcomes and response to potential therapies.
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              Functional status of elderly adults before and after initiation of dialysis.

              It is unclear whether functional status before dialysis is maintained after the initiation of this therapy in elderly patients with end-stage renal disease (ESRD). Using a national registry of patients undergoing dialysis, which was linked to a national registry of nursing home residents, we identified all 3702 nursing home residents in the United States who were starting treatment with dialysis between June 1998 and October 2000 and for whom at least one measurement of functional status was available before the initiation of dialysis. Functional status was measured by assessing the degree of dependence in seven activities of daily living (on the Minimum Data Set-Activities of Daily Living [MDS-ADL] scale of 0 to 28 points, with higher scores indicating greater functional difficulty). The median MDS-ADL score increased from 12 during the 3 months before the initiation of dialysis to 16 during the 3 months after the initiation of dialysis. Three months after the initiation of dialysis, functional status had been maintained in 39% of nursing home residents, but by 12 months after the initiation of dialysis, 58% had died and predialysis functional status had been maintained in only 13%. In a random-effects model, the initiation of dialysis was associated with a sharp decline in functional status, indicated by an increase of 2.8 points in the MDS-ADL score (95% confidence interval [CI], 2.5 to 3.0); this decline was independent of age, sex, race, and functional-status trajectory before the initiation of dialysis. The decline in functional status associated with the initiation of dialysis remained substantial (1.7 points; 95% CI, 1.4 to 2.1), even after adjustment for the presence or absence of an accelerated functional decline during the 3-month period before the initiation of dialysis. Among nursing home residents with ESRD, the initiation of dialysis is associated with a substantial and sustained decline in functional status. 2009 Massachusetts Medical Society
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                Author and article information

                Journal
                enefro
                Enfermería Nefrológica
                Enferm Nefrol
                Sociedad Española de Enfermería Nefrológica (Madrid, Madrid, Spain )
                2254-2884
                2255-3517
                September 2023
                : 26
                : 3
                : 268-276
                Affiliations
                [3] orgnameInstituto Maimónides de Investigación Biomédica de Córdoba España
                [2] orgnameHospital Universitario Reina Sofía de Córdoba orgdiv1Servicio de Nefrología España
                [1] Andalucía orgnameUniversidad de Córdoba orgdiv1Departamento de Enfermería orgdiv2Facultad de Medicina y Enfermería Spain
                Article
                S2254-28842023000300008 S2254-2884(23)02600300008
                10.37551/s2254-28842023026
                5c5080e9-bd42-413f-a7f8-31c5ed4da57d

                This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

                History
                : 03 August 2023
                : 20 August 2023
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 31, Pages: 9
                Product

                SciELO Spain

                Categories
                Originales

                frailty,activities of daily living,predialysis,CKD,health-related quality of life,ERCA,prediálisis,fragilidad,calidad de vida relacionada con la salud,actividades básicas de la vida diaria

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