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      The Secret Life of ACE2 as a Receptor for the SARS Virus

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      Cell
      Cell Press.

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          Abstract

          The membrane-associated carboxypeptidase angiotensin-converting enzyme 2 (ACE2) is an essential regulator of heart function. Now, Li at al. identify and characterize an unexpected second function of ACE2 as a partner of the SARS-CoV spike glycoprotein in mediating virus entry and cell fusion.

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          Author and article information

          Contributors
          Journal
          Cell
          Cell
          Cell
          Cell Press.
          0092-8674
          1097-4172
          16 December 2003
          12 December 2003
          16 December 2003
          : 115
          : 6
          : 652-653
          Affiliations
          Human Immunovirology and Computational Biology Group, LECB, CCR, NCI-Frederick, NIH, Frederick, MD 21702 USA
          Author notes
          [* ]Correspondence: Dimiter S. Dimitrov dimitrov@ 123456ncifcrf.gov
          Article
          S0092-8674(03)00976-0
          10.1016/S0092-8674(03)00976-0
          7133233
          14675530
          5c5c82a9-8d2f-4b9b-bfa6-69fc44f6e800
          Copyright © 2003 Cell Press. All rights reserved.

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          Cell biology
          Cell biology

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