We report here a simple method to prepare and characterize analytically-pure NBu 4SH, which provides access to an organic-soluble source of HS −.
Hydrogen sulfide (H 2S) has gained significant interest within the scientific community due to its expanding roles in different (patho)physiological processes. Despite this importance, the chemical mechanisms by which H 2S exerts its action remain under-scrutinized. Biomimetic investigations in organic solution offer the potential to clarify these mechanisms and to delineate the differential reactivity between H 2S and HS −. However, such studies are hampered by the lack of readily-available sources of HS − that are soluble in organic solution. Here we present a simple method for preparing analytically pure tetrabutylammonium hydrosulfide (NBu 4SH), which we anticipate will be of significant utility to researchers in the H 2S and anion-binding communities.