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      Effort, avolition and motivational experience in schizophrenia: Analysis of behavioral and neuroimaging data with relationships to daily motivational experience

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          Abstract

          Recent research suggests that schizophrenia is associated with reduced effort allocation. We examined willingness to expend effort, neural correlates of effort allocation, and the relationship of effort to daily motivational experience in schizophrenia. We recruited 28 individuals with schizophrenia and 30 controls to perform an effort task during fMRI. Individuals with schizophrenia also completed an ecological momentary assessment (EMA) protocol. Individuals with schizophrenia with high negative symptoms were less willing to expend effort for rewards. Daily EMA assessments of motivation were positively associated with effort allocation at a trend-level. Individuals with schizophrenia and controls displayed similar increases in BOLD activation in frontal, cingulate, parietal, and insular regions during effort-based decision-making. However, negative symptoms were associated with reduced BOLD activation in bilateral ventral striatum. These results replicate previous reports of reduced effort allocation in schizophrenia patients with severe negative symptoms, and provide evidence for the role of ventral striatum in effort impairments.

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          Author and article information

          Journal
          101601751
          41001
          Clin Psychol Sci
          Clin Psychol Sci
          Clinical psychological science : a journal of the Association for Psychological Science
          2167-7026
          2167-7034
          15 January 2020
          22 April 2020
          1 May 2020
          22 March 2021
          : 8
          : 3
          : 555-568
          Affiliations
          [1 ]Department of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, MO 63130
          [2 ]Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110
          [3 ]Department of Cognitive, Linguistics, and Psychological Sciences, Brown University, Providence, RI 02906
          [4 ]Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 EN Nijmegen, The Netherlands
          [5 ]Department of Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110
          Author notes
          [* ]Adam Culbreth, Ph.D., Washington University in St. Louis, Department of Psychological and Brain Sciences, Box 1125, One Brookings Drive, St. Louis, MO 63130, Phone: 314-935-8547, Fax: 314-935-8790, aculbreth@ 123456wustl.edu
          Article
          PMC7983405 PMC7983405 7983405 nihpa1548171
          10.1177/2167702620901558
          7983405
          33758684
          5c7f87ec-1176-458b-a2ed-2f35264592fd
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          Article

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