Ketogenic diet leads to O-GlcNAc modification in the BTBR(T+tf/j) mouse model of autism.

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Abstract

Protein O-linked-β-N-acetyl glucosamine (O-GlcNAc) is a post-translational modification to Ser/Thr residues that integrates energy supply with demand. Abnormal O-GlcNAc patterning is evident in several neurological disease states including epilepsy, Alzheimer's disease and autism spectrum disorder (ASD). A potential treatment option for these disorders includes the high-fat, low-carbohydrate, ketogenic diet (KD). The goal of this study was to determine whether the KD induces changes in O-GlcNAc in the BTBR(T+tf/j) (BTBR) mouse model of ASD.

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Journal ID (iso-abbrev): Biochim. Biophys. Acta

Title: Biochimica et biophysica acta

Publisher: Elsevier BV

ISSN: 0006-3002

ISSN (Print): 0006-3002

Publication date (Electronic): May 11 2017

Affiliations

[1 ] Faculty of Kinesiology, University of Calgary, Calgary, AB, Canada; Department of Medical Science, University of Calgary Cumming School of Medicine, Calgary, AB, Canada. Electronic address: cnewell@ucalgary.ca.

[2 ] Faculty of Kinesiology, University of Calgary, Calgary, AB, Canada.

[3 ] Alberta Children's Hospital Research Institute, University of Calgary Cumming School of Medicine, Alberta Children's Hospital, AB, Canada.

[4 ] Department of Medical Science, University of Calgary Cumming School of Medicine, Calgary, AB, Canada.

[5 ] Alberta Children's Hospital Research Institute, University of Calgary Cumming School of Medicine, Alberta Children's Hospital, AB, Canada; Department of Medical Genetics and Pediatrics, University of Calgary Cumming School of Medicine, Alberta Children's Hospital, AB, Canada.

[6 ] Alberta Children's Hospital Research Institute, University of Calgary Cumming School of Medicine, Alberta Children's Hospital, AB, Canada; Department of Paediatrics, University of Calgary Cumming School of Medicine, Alberta Children's Hospital, Calgary, AB, Canada; Department of Clinical Neurosciences, University of Calgary Cumming School of Medicine, Alberta Children's Hospital, Calgary, AB, Canada; Department of Physiology & Pharmacology, University of Calgary Cumming School of Medicine, Alberta Children's Hospital, Calgary, AB, Canada.

[7 ] Faculty of Kinesiology, University of Calgary, Calgary, AB, Canada; Department of Medical Science, University of Calgary Cumming School of Medicine, Calgary, AB, Canada; Alberta Children's Hospital Research Institute, University of Calgary Cumming School of Medicine, Alberta Children's Hospital, AB, Canada.

Article

Publisher Item ID: S0925-4439(17)30150-3

DOI: 10.1016/j.bbadis.2017.05.013

PubMed ID: 28502704

SO-VID: 5c9050d0-188e-4853-ae46-c3ccc83d5d45

History

Keywords: Autism spectrum disorder,Ketogenic diet,Metabolism,Post-translational modification,Protein O-linked-β-N-acetyl glucosamine

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Keywords: Autism spectrum disorder, Ketogenic diet, Metabolism, Post-translational modification, Protein O-linked-β-N-acetyl glucosamine

Ketogenic diet leads to O-GlcNAc modification in the BTBR(T+tf/j) mouse model of autism.

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