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      APOL1 variants in HIV-associated nephropathy: just one piece of the puzzle

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      Kidney International

      Springer Nature America, Inc

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          Abstract

          Considerable attention has been focused on how the APOL1/MYH9 locus determines susceptibility to focal segmental glomerulosclerosis, including HIV-associated nephropathy (HIVAN). Atta and colleagues found that homozygosity for APOL1 risk alleles was associated with many, but not all, HIVAN cases, and that APOL1 variation failed to predict characteristics of disease. Their work gives important impetus to identify other genetic and environmental factors that may provide a 'second hit' linking HIV infection to HIVAN.

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          Author and article information

          Journal
          Kidney International
          Kidney International
          Springer Nature America, Inc
          00852538
          August 2012
          August 2012
          : 82
          : 3
          : 259-260
          Article
          10.1038/ki.2012.129
          22791322
          © 2012

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