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      Síndromes paraneoplásicos en tumores gastrointestinales. Revisión de tema Translated title: A Review of Paraneoplastic Syndromes in Gastrointestinal Tumors

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          Abstract

          Resumen Los síndromes paraneoplásicos representan manifestaciones clínicas que producen los tumores en sitios distantes a ellos y que no están relacionadas físicamente con ellos ni con sus metástasis. Diferentes tumores gastrointestinales pueden presentar síndromes o manifestaciones sistémicas, dermatológicas, hematológicas, renales y neurológicas, entre otras. Aquí se ofrece una revisión de esas distintas manifestaciones.

          Translated abstract

          Abstract Paraneoplastic syndromes produce tumors at sites distant from themselves and are not physically related to those tumors or to their metastases. Various gastrointestinal tumors may present syndromes or systemic, dermatological, hematological, renal, neurological and other manifestations. This study reviews these manifestations.

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          Epidemiology of cancer-associated venous thrombosis.

          Jasmijn F. Timp, Sigrid K Braekkan, Henri Versteeg … (2013)
          Cancer-associated venous thrombosis is a common condition, although the reported incidence varies widely between studies depending on patient population, start and duration of follow-up, and the method of detecting and reporting thrombotic events. Furthermore, as cancer is a heterogeneous disease, the risk of venous thrombosis depends on cancer types and stages, treatment measures, and patient-related factors. In general, cancer patients with venous thrombosis do not fare well and have an increased mortality compared with cancer patients without. This may be explained by the more aggressive type of malignancies associated with this condition. It is hypothesized that thromboprophylaxis in cancer patients might improve prognosis and quality of life by preventing thrombotic events. However, anticoagulant treatment leads to increased bleeding, particularly in this patient group, so in case of proven benefit of thromboprophylaxis, only patients with a high risk of venous thrombosis should be considered. This review describes the literature on incidence of and risk factors for cancer-associated venous thrombosis, with the aim to provide a basis for identification of high-risk patients and for further development and refinement of prediction models. Furthermore, knowledge on risk factors for cancer-related venous thrombosis may enhance the understanding of the pathophysiology of thrombosis in these patients.
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            Clinical practice. Hypercalcemia associated with cancer.

            Andrew F Stewart (2005)
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              Paraneoplastic syndromes: an approach to diagnosis and treatment.

              Lorraine C Pelosof, Brian Gerber (2010)
              Recent medical advances have improved the understanding, diagnosis, and treatment of paraneoplastic syndromes. These disorders arise from tumor secretion of hormones, peptides, or cytokines or from immune cross-reactivity between malignant and normal tissues. Paraneoplastic syndromes may affect diverse organ systems, most notably the endocrine, neurologic, dermatologic, rheumatologic, and hematologic systems. The most commonly associated malignancies include small cell lung cancer, breast cancer, gynecologic tumors, and hematologic malignancies. In some instances, the timely diagnosis of these conditions may lead to detection of an otherwise clinically occult tumor at an early and highly treatable stage. Because paraneoplastic syndromes often cause considerable morbidity, effective treatment can improve patient quality of life, enhance the delivery of cancer therapy, and prolong survival. Treatments include addressing the underlying malignancy, immunosuppression (for neurologic, dermatologic, and rheumatologic paraneoplastic syndromes), and correction of electrolyte and hormonal derangements (for endocrine paraneoplastic syndromes). This review focuses on the diagnosis and treatment of paraneoplastic syndromes, with emphasis on those most frequently encountered clinically. Initial literature searches for this review were conducted using PubMed and the keyword paraneoplastic in conjunction with keywords such as malignancy, SIADH, and limbic encephalitis, depending on the particular topic. Date limitations typically were not used, but preference was given to recent articles when possible.
              Article 0 comments Cited 188 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Laura Rodríguez P: Role: ND
                James Yurgaky S: Role: ND
                William Otero R: Role: ND
                Michel Faizal: Role: ND
                Journal
                Journal ID (publisher-id): rcg
                Title: Revista Colombiana de Gastroenterologia
                Abbreviated Title: Rev Col Gastroenterol
                Publisher: Asociación Colombiana de Gastroenterología (Bogotá, , Colombia )
                ISSN (Print): 0120-9957
                Publication date (Print and electronic): September 2017
                Volume: 32
                Issue: 3
                Pages: 230-244
                Affiliations
                [1] Bogotá orgnameUniversidad Nacional de Colombia Colombia
                [4] orgnameUniversidad Nacional de Colombia orgdiv1Unidad de Dermatología Colombia
                [3] Bogotá orgnameUniversidad Nacional de Colombia orgdiv1Unidad de Gastroenterología Colombia waoteror@ 123456gmail.com
                [2] Bogotá orgnameUniversidad Nacional de Colombia Colombia
                Article
                Publisher ID: S0120-99572017000300230
                DOI: 10.22516/25007440.155
                SO-VID: 5cb8b5ef-cd21-4392-a832-f4795d0de131
                License:

                This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

                History
                Date accepted : 28 July 2017
                Date received : 25 July 2016
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 108, Pages: 15
                Product

                SciELO Colombia


                Keywords: Síndrome paraneoplásico,gastrointestinal,tumores,Paraneoplastic syndrome,tumors
                Data availability:
                Keywords: Síndrome paraneoplásico, gastrointestinal, tumores, Paraneoplastic syndrome, tumors

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