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      Bioprospecting freshwater microalgae for antibacterial activity from water bodies associated with abandoned mine sites

      1 , 2 , 1 , 2
      Phycologia
      International Phycological Society

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          The effects of climatic warming on the properties of boreal lakes and streams at the Experimental Lakes Area, northwestern Ontario

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            Is Open Access

            Screening of cyanobacteria and microalgae for their ability to synthesize silver nanoparticles with antibacterial activity

            The aim of this study was to assess the ability of selected strains of cyanobacteria and microalgae to biosynthesize silver nanoparticles (Ag-NPs) by using two procedures; (i) suspending the live and washed biomass of microalgae and cyanobacteria into the AgNO3 solution and (ii) by adding AgNO3 into a cell-free culture liquid. Ag-NPs were biosynthesized by 14 out of 16 tested strains. In most of the cases Ag-NPs were formed both in the presence of biomass as well as in the cell-free culture liquid. This indicates that the process of Ag-NPs formation involves an extracellular compound such as polysaccharide. TEM analysis showed that the nanoparticles were embedded within an organic matrix. Ag-NPs varied in shape and sizes that ranged between 13 and 31 nm, depending on the organism used. The antibacterial activity of Ag-NPs was confirmed in all but one strain of cyanobacterium (Limnothrix sp. 37-2-1) which formed the largest particles.
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              New aspects of natural products in drug discovery.

              During the past 15 years, most large pharmaceutical companies have decreased the screening of natural products for drug discovery in favor of synthetic compound libraries. Main reasons for this include the incompatibility of natural product libraries with high-throughput screening and the marginal improvement in core technologies for natural product screening in the late 1980s and early 1990 s. Recently, the development of new technologies has revolutionized the screening of natural products. Applying these technologies compensates for the inherent limitations of natural products and offers a unique opportunity to re-establish natural products as a major source for drug discovery. Examples of these new advances and technologies are described in this review.
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                Author and article information

                Journal
                Phycologia
                Phycologia
                International Phycological Society
                0031-8884
                July 2018
                July 2018
                : 57
                : 4
                : 432-439
                Affiliations
                [1 ]Biomolecular Sciences Program, Laurentian University, Ramsey Lake Rd, Sudbury, Ontario P3E 2C6, Canada
                [2 ]Bharti School of Engineering, Laurentian University, Ramsey Lake Rd, Sudbury, Ontario P3E 2C6, Canada
                Article
                10.2216/17-114.1
                5cbe8ddb-33d3-49ee-9bed-adef5470b4fc
                © 2018
                History

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