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      The Effect of Acute Metabolic Acidosis on Plasma Cortisol, Renin Activity and Aldosterone

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          Abstract

          The effect of metabolic acidosis on the renin-aldosterone system remains unclear. In the present study anesthetized mongrel dogs (n = 19) were infused at similar rates with 0.45% NaCl (controls), HCl or NH<sub>4</sub>Cl (2.5mEq/kg) for 1-3 h. The induced metabolic acidosis in the two experimental groups was not associated with increases in plasma renin activity. Plasma cortisol (as a marker for ACTH secretion) and serum potassium concentration increased in both HCl- and NH<sub>4</sub>Cl-treated animals. Plasma aldosterone increased after 30 min in the HCl group and 60 min in the NH<sub>4</sub>C1 group and did not change in controls. These findings demonstrate that metabolic acidosis induced by HCl or NH<sub>4</sub>Cl is associated with increased aldosterone production without concomitant changes in plasma renin activity.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1979
          1979
          25 November 2008
          : 11
          : 1
          : 12-21
          Affiliations
          Medical and Research Services, Veterans Administration Hospital and the Department of Medicine, University of Miami School of Medicine, Miami, Fla., and Medical Service, Veterans Administration Hospital and Department of Medicine, University of Colorado School of Medicine, Denver, Colo.
          Article
          179033 Horm Res 1979;11:12–21
          10.1159/000179033
          39026
          © 1979 S. Karger AG, Basel

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          Page count
          Pages: 10
          Categories
          Original Paper

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