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      The Effect of Acute Metabolic Acidosis on Plasma Cortisol, Renin Activity and Aldosterone

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          The effect of metabolic acidosis on the renin-aldosterone system remains unclear. In the present study anesthetized mongrel dogs (n = 19) were infused at similar rates with 0.45% NaCl (controls), HCl or NH<sub>4</sub>Cl (2.5mEq/kg) for 1-3 h. The induced metabolic acidosis in the two experimental groups was not associated with increases in plasma renin activity. Plasma cortisol (as a marker for ACTH secretion) and serum potassium concentration increased in both HCl- and NH<sub>4</sub>Cl-treated animals. Plasma aldosterone increased after 30 min in the HCl group and 60 min in the NH<sub>4</sub>C1 group and did not change in controls. These findings demonstrate that metabolic acidosis induced by HCl or NH<sub>4</sub>Cl is associated with increased aldosterone production without concomitant changes in plasma renin activity.

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          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          25 November 2008
          : 11
          : 1
          : 12-21
          Medical and Research Services, Veterans Administration Hospital and the Department of Medicine, University of Miami School of Medicine, Miami, Fla., and Medical Service, Veterans Administration Hospital and Department of Medicine, University of Colorado School of Medicine, Denver, Colo.
          179033 Horm Res 1979;11:12–21
          © 1979 S. Karger AG, Basel

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          Pages: 10
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