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      Melanotropes of the Lizard, Anolis carolinensis, Lack N-Acetylating Mechanisms for Both Alpha-Melanocyte-Stimulating Hormone and Beta-Endorphin

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          Abstract

          In order to determine whether A nolis carolinensis intermediate pituitary cells have the capacity to N-acetylate either ACTH(1-13)NH2 or β-endorphin during secretion, individual intermediate pituitary explants were incubated in DMEM/CO<sub>2</sub> for 24 h at 28°C. Although α-melanocyte-stimulating hormone (α-MSH)- and β-endorphin-related products were spontaneously released into the medium, none of these forms were N-acetylated. It appears that unlike most gnathostomes, A. carolinensis has secondarily lost the POMC-specific N-acetylation mechanisms. A ramification of this observation is that the α-MSH for A. carolinensis is ACTH (1-13)NH<sub>2</sub>.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1994
          1994
          08 April 2008
          : 59
          : 6
          : 603-609
          Affiliations
          aDepartment of Biological Sciences, University of Denver, Denver, Colo., USA; bDepartment of Applied Biology, University of Rouen, Mont-Saint-Aignan, France; cDepartamento de Biologia Celular, Facultad de Biologia, Universidad de La Laguna, Tenerife, Spain
          Article
          126710 Neuroendocrinology 1994;59:603–609
          10.1159/000126710
          8084383
          © 1994 S. Karger AG, Basel

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          Page count
          Pages: 7
          Categories
          Corticotropic Axis

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