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      Melanotropes of the Lizard, Anolis carolinensis, Lack N-Acetylating Mechanisms for Both Alpha-Melanocyte-Stimulating Hormone and Beta-Endorphin

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          Abstract

          In order to determine whether A nolis carolinensis intermediate pituitary cells have the capacity to N-acetylate either ACTH(1-13)NH2 or β-endorphin during secretion, individual intermediate pituitary explants were incubated in DMEM/CO<sub>2</sub> for 24 h at 28°C. Although α-melanocyte-stimulating hormone (α-MSH)- and β-endorphin-related products were spontaneously released into the medium, none of these forms were N-acetylated. It appears that unlike most gnathostomes, A. carolinensis has secondarily lost the POMC-specific N-acetylation mechanisms. A ramification of this observation is that the α-MSH for A. carolinensis is ACTH (1-13)NH<sub>2</sub>.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1994
          1994
          08 April 2008
          : 59
          : 6
          : 603-609
          Affiliations
          aDepartment of Biological Sciences, University of Denver, Denver, Colo., USA; bDepartment of Applied Biology, University of Rouen, Mont-Saint-Aignan, France; cDepartamento de Biologia Celular, Facultad de Biologia, Universidad de La Laguna, Tenerife, Spain
          Article
          126710 Neuroendocrinology 1994;59:603–609
          10.1159/000126710
          8084383
          5ccd31d7-1850-4820-a73f-7f903d985098
          © 1994 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 14 October 1993
          : 07 January 1994
          Page count
          Pages: 7
          Categories
          Corticotropic Axis

          Endocrinology & Diabetes,Neurology,Nutrition & Dietetics,Sexual medicine,Internal medicine,Pharmacology & Pharmaceutical medicine
          </italic>Alpha-melanocyte-stimulating hormone,<italic>Anolis carolinensis,Beta-endorphin

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