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      Infusion of neurosteroids into the nucleus basalis magnocellularis affects cognitive processes in the rat

      , , , , , ,
      Brain Research
      Elsevier BV

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          Abstract

          The neurosteroids, pregnenolone sulfate (PREG-S) and tetrahydroprogesterone (TH-PROG), act on the GABAA receptor with antagonist or agonist-like properties, respectively. In this study the effect of the infusion of PREG-S and TH-PROG into the nucleus basalis magnocellularis (NBM) of the rat was examined in a two-trial memory task. The results show that PREG-S (5 ng in 0.5 microliter) enhances memory performance when injected after an acquisition trial; conversely TH-PROG (2 ng in 0.5 microliter) disrupts performance when injected before an acquisition trial. A role for neurosteroids in memory processes subserved by the nucleus basalis magnocellularis is of interest in view of the implication of this structure and these substances in neurodegenerative processes.

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          Author and article information

          Journal
          Brain Research
          Brain Research
          Elsevier BV
          00068993
          April 1993
          April 1993
          : 607
          : 1-2
          : 324-328
          Article
          10.1016/0006-8993(93)91524-V
          8386975
          5cdd60c2-e138-42c0-8178-7b4e66dfacbb
          © 1993

          https://www.elsevier.com/tdm/userlicense/1.0/

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