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      YAP/TAZ at the roots of cancer

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      Cancer cell

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          Summary

          YAP and TAZ are highly related transcriptional regulators pervasively activated in human malignancies. Recent work indicates that, remarkably, YAP/TAZ are essential for cancer initiation or growth of most solid tumors. Their activation induces cancer stem cells attributes, proliferation, chemoresistance and metastasis. YAP/TAZ are sensors of the structural and mechanical features of the cell microenvironment. A number of cancer-associated extrinsic and intrinsic cues conspire to overrule the YAP-inhibiting microenvironment of normal tissues, including changes in mechanotransduction, inflammation, oncogenic signaling and inhibition of the Hippo pathway. Addiction to YAP/TAZ thus potentially represents a central cancer vulnerability that may be exploited therapeutically.

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          Author and article information

          Journal
          101130617
          29778
          Cancer Cell
          Cancer Cell
          Cancer cell
          1535-6108
          1878-3686
          9 October 2018
          13 June 2016
          14 October 2018
          : 29
          : 6
          : 783-803
          Affiliations
          Department of Molecular Medicine, University of Padua School of Medicine, viale Colombo 3, 35126 Padua, Italy. Tel +390498276098
          Author notes
          Article
          PMC6186419 PMC6186419 6186419 ems79998
          10.1016/j.ccell.2016.05.005
          6186419
          27300434
          5cddf581-c418-4fd7-a4e8-87e5bd13e225
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