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      FMRI visualization of brain activity during a monetary incentive delay task.

      1 , , ,

      NeuroImage

      Elsevier BV

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          Abstract

          Comparative studies have implicated striatal and mesial forebrain circuitry in the generation of autonomic, endocrine, and behavioral responses for incentives. Using blood oxygen level-dependent functional magnetic resonance imaging, we sought to visualize functional activation of these regions in 12 normal volunteers as they anticipated and responded for monetary incentives. Both individual and group analyses of time-series data revealed significant activation of striatal and mesial forebrain structures (including insula, caudate, putamen, and mesial prefrontal cortex) during trials involving both monetary rewards and punishments. In addition to these areas, during trials involving punishment, group analysis revealed activation foci in the anterior cingulate and thalamus. These results corroborate comparative studies which implicate striatal and mesial forebrain circuitry in the elaboration of incentive-driven behavior. This report also introduces a new paradigm for probing the functional integrity of this circuitry in humans.

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          Author and article information

          Journal
          Neuroimage
          NeuroImage
          Elsevier BV
          1053-8119
          1053-8119
          Jul 2000
          : 12
          : 1
          Affiliations
          [1 ] Section of Brain Electrophysiology and Imaging, National Institutes of Health, Bethesda, Maryland, 20892-1610, USA.
          Article
          S1053-8119(00)90593-7
          10.1006/nimg.2000.0593
          10875899
          5d26fcc6-dad6-43d8-a76c-cff33c3945b8

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