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      Standardization of relative centrifugal forces in studies related to platelet‐rich fibrin

      1 , 2 , 3 , 4 , 4 , 5
      Journal of Periodontology
      Wiley

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          Comparative release of growth factors from PRP, PRF, and advanced-PRF.

          The use of platelet concentrates has gained increasing awareness in recent years for regenerative procedures in modern dentistry. The aim of the present study was to compare growth factor release over time from platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and a modernized protocol for PRF, advanced-PRF (A-PRF).
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            Optimized Platelet-Rich Fibrin With the Low-Speed Concept: Growth Factor Release, Biocompatibility, and Cellular Response.

            Over the past decade, use of leukocyte platelet-rich fibrin (L-PRF) has gained tremendous momentum in regenerative dentistry as a low-cost fibrin matrix used for tissue regeneration. This study characterizes how centrifugation speed (G-force) along with centrifugation time influence growth factor release from fibrin clots, as well as the cellular activity of gingival fibroblasts exposed to each PRF matrix.
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              Is Open Access

              Regenerative potential of leucocyte‐ and platelet‐rich fibrin. Part A: intra‐bony defects, furcation defects and periodontal plastic surgery. A systematic review and meta‐analysis

              Abstract Aim To analyse the regenerative potential of leucocyte‐ and platelet‐rich fibrin (L‐PRF) during periodontal surgery. Materials and Methods An electronic and hand search were conducted in three databases. Only randomized clinical trials were selected and no follow‐up limitation was applied. Pocket depth (PD), clinical attachment level (CAL), bone fill, keratinized tissue width (KTW), recession reduction and root coverage (%) were considered as outcome. When possible, meta‐analysis was performed. Results Twenty‐four articles fulfilled the inclusion and exclusion criteria. Three subgroups were created: intra‐bony defects (IBDs), furcation defects and periodontal plastic surgery. Meta‐analysis was performed in all the subgroups. Significant PD reduction (1.1 ± 0.5 mm, p   0.05), CAL gain (0.2 ± 0.5 mm, p > 0.05), KTW (0.3 ± 0.4 mm, p > 0.05) and recession reduction (0.2 ± 0.3 mm, p > 0.05). Conclusions L‐PRF enhances periodontal wound healing.
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                Author and article information

                Journal
                Journal of Periodontology
                J Periodontol
                Wiley
                0022-3492
                1943-3670
                June 02 2019
                August 2019
                March 2019
                August 2019
                : 90
                : 8
                : 817-820
                Affiliations
                [1 ]Department of PeriodontologyUniversity of Bern Bern Switzerland
                [2 ]Post‐Doctoral Periodontology ProgramLaboratory for Immunoregulation and Tissue Engineering (LITE)Division of Periodontology, Diagnostic Sciences & Dental HygieneUniversity of Southern California, Ostrow School of Dentistry Los Angeles CA USA
                [3 ]Department of Periodontology and Implant DentistryUniversity of the Andes (UANDES) Santiago Chile
                [4 ]Department of Oral Health SciencesKatholieke Universiteit Leuven (KUL)Department of PeriodontologyUniversity Hospitals Leuven Leuven Belgium
                [5 ]FORMFrankfurt Oral Regenerative MedicineClinic for Maxillofacial and Plastic SurgeryJohann Wolfgang Goethe University Frankfurt Am Main Germany
                Article
                10.1002/JPER.18-0553
                30730050
                5d35df5d-e777-4748-8cf7-80a105588c82
                © 2019

                http://onlinelibrary.wiley.com/termsAndConditions#vor

                http://doi.wiley.com/10.1002/tdm_license_1.1

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