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      Return to Work and Risk of Subsequent Detachment From Employment After Myocardial Infarction: Insights From Danish Nationwide Registries

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          Abstract

          Background

          Limited data are available on return to work and subsequent detachment from employment after admission for myocardial infarction ( MI).

          Methods and Results

          Using individual‐level linkage of data from nationwide registries, we identified patients of working age (30–65 years) discharged after first‐time MI in the period 1997 to 2012, who were employed before admission. To assess the cumulative incidence of return to work and detachment from employment, the Aalen Johansen estimator was used. Incidences were compared with population controls matched on age and sex. Logistic regression was applied to estimate odds ratios for associations between detachment from employment and age, sex, comorbidities, income, and education level. Of 39 296 patients of working age discharged after first‐time MI, 22 394 (56.9%) were employed before admission. Within 1 year 91.1% (95% confidence interval [ CI], 90.7%–91.5%) of subjects had returned to work, but 1 year after their return 24.2% (95% CI, 23.6%–24.8%) were detached from employment and received social benefits. Detachment rates were highest in patients aged 60 to 65 and 30 to 39 years, and significantly higher in patients with MI compared with population controls. Predictors of detachment were heart failure (odds ratio 1.20 [95% CI, 1.08–1.34]), diabetes mellitus (odds ratio 1.13 [95% CI, 1.01–1.25]), and depression (odds ratio 1.77 [95% CI, 1.55–2.01]). High education level and high income favored continued employment.

          Conclusions

          Despite that most patients returned to work after first‐time MI, about 1 in 4 was detached from employment after 1 year. Several factors including age and lower socioeconomic status were associated with risk of detachment from employment.

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          Most cited references27

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          Impact of age on management and outcome of acute coronary syndrome: observations from the Global Registry of Acute Coronary Events (GRACE).

          Evidence-based cardiac therapies are underutilized in elderly patients. We assessed differences in practice patterns, comorbidities, and in-hospital event rates, by age and type of acute coronary syndrome (ACS). We studied 24165 ACS patients in 102 hospitals in 14 countries stratified by age. Approximately two-thirds of patients were men, but this proportion decreased with age. In elderly patients (> or = 65 years), history of angina, transient ischemic attack/stroke, myocardial infarction(MI), congestive heart failure, coronary artery bypass graft (CABG) surgery, hypertension or atrial fibrillation were more common, and delay in seeking medical attention and non-ST-segment elevation MI were significantly higher. Aspirin, beta-blockers, thrombolytic therapy, statins and glycoprotein IIb/IIIa inhibitors were prescribed less, while calcium antagonists and angiotensin-converting enzyme inhibitors were prescribed more often to elderly patients. Unfractionated heparin was prescribed more often in young patients, while low-molecular-weight heparins were similarly prescribed across all age groups. Coronary angiography and percutaneous intervention rates significantly decreased with age. The rate of CABG surgery was highest among patients aged 65-74 years (8.1%) and 55-64 years (7.7%), but reduced in the youngest (4.7%) and oldest (2.7%) groups. Major bleeding rates were 2-3% among patients aged 6% in those > or = 85 years. Hospital-mortality rates, adjusted for baseline risk differences, increased with age (odds ratio: 15.7 in patients > or = 85 years compared with those < 45 years). Many elderly ACS patients do not receive evidence-based therapies, highlighting the need for clinical trials targeted specifically at elderly cohorts, and quality-of-care programs that reinforce the use of such therapies among these individuals.
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            Health status predicts long-term outcome in outpatients with coronary disease.

            Although patient-reported health status measures have been used as end points in clinical trials, they are rarely used in other settings. Demonstrating that they independently predict mortality and hospitalizations among outpatients with coronary disease could emphasize their clinical value. This study evaluated the prognostic utility of the Seattle Angina Questionnaire (SAQ), a disease-specific health status measure for patients with coronary artery disease. Patients were enrolled in a prospective cohort study from 6 Veterans Affairs General Internal Medicine Clinics. All patients reporting coronary artery disease who completed a SAQ and had 1 year of follow-up were analyzed (n=5558). SAQ predictor variables were the physical limitation, angina stability, angina frequency, and quality-of-life scores. The primary outcome was 1-year all-cause mortality, and a secondary outcome was hospitalization for acute coronary syndrome (ACS). Lower SAQ scores were associated with increased risks of mortality and ACS admissions. Prognostic models controlling for demographic and clinical characteristics demonstrated significant independent mortality risk with lower SAQ physical limitation scores; odds ratios for mild, moderate, and severe limitation were 1.5, 2.0, and 4.0 versus minimal limitation (P<0.001). Odds ratios for mild, moderate, and severe angina frequency were 0.8, 1.2, and 1.6 (P=0.078). The odds ratios for ACS admission among those with mild, moderate, and severe angina frequency were 1.4, 2.0, and 2.2, respectively (P=0.016). SAQ scores are independently associated with 1-year mortality and ACS among outpatients with coronary disease and may serve a valuable role in the risk stratification of such patients.
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              Job decision latitude, job demands, and cardiovascular disease: a prospective study of Swedish men.

              The association between specific job characteristics and subsequent cardiovascular disease was tested using a large random sample of the male working Swedish population. The prospective development of coronary heart disease (CHD) symptoms and signs was analyzed using a multivariate logistic regression technique. Additionally, a case-controlled study was used to analyze all cardiovascular-cerebrovascular (CHD-CVD) deaths during a six-year follow-up. The indicator of CHD symptoms and signs was validated in a six-year prospective study of CHD deaths (standardized mortality ratio 5.0; p less than or equal to .001). A hectic and psychologically demanding job increases the risk of developing CHD symptoms and signs (standardized odds ratio 1.29, p less than 0.25) and premature CHD-CVD death (relative risk 4.0, p less than .01). Low decision latitude-expressed as low intellectual discretion and low personal schedule freedom-is also associated with increased risk of cardiovascular disease. Low intellectual discretion predicts the development of CHD symptoms and signs (SOR 1.44, p less than .01), while low personal schedule freedom among the majority of workers with the minimum statutory education increases the risk of CHD-CVD death (RR 6.6, p less than .0002). The associations exist after controlling for age, education, smoking, and overweight.
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                Author and article information

                Contributors
                LaerkeSmedegaard@gmail.com
                Journal
                J Am Heart Assoc
                J Am Heart Assoc
                10.1002/(ISSN)2047-9980
                JAH3
                ahaoa
                Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
                John Wiley and Sons Inc. (Hoboken )
                2047-9980
                04 October 2017
                October 2017
                : 6
                : 10 ( doiID: 10.1002/jah3.2017.6.issue-10 )
                : e006486
                Affiliations
                [ 1 ] Department of Cardiology Copenhagen University Herlev Gentofte Hospital Hellerup Denmark
                [ 2 ] Departments of Cardiology and Epidemiology/Biostatistics Aalborg University Hospital Aalborg Denmark
                [ 3 ] The Institute of Public Health University of Southern Denmark Copenhagen Denmark
                [ 4 ] Faculty of Health & Medical Sciences University of Copenhagen Denmark
                [ 5 ] The Danish Heart Foundation Copenhagen Denmark
                Author notes
                [*] [* ] Correspondence to: Laerke Smedegaard, MD, Department of Cardiology, Copenhagen University, Herlev Gentofte Hospital, Kildegaardsvej 28, 2900 Hellerup, Denmark. E‐mail: LaerkeSmedegaard@ 123456gmail.com
                Article
                JAH32619
                10.1161/JAHA.117.006486
                5721858
                28978528
                5d4238e0-f708-4dd0-9bc7-ace8d66baff6
                © 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

                This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

                History
                : 27 April 2017
                : 28 August 2017
                Page count
                Figures: 6, Tables: 4, Pages: 12, Words: 7519
                Funding
                Funded by: Danish Agency for Science, Technology and Innovation
                Funded by: Danish Council for Strategic Research
                Award ID: 09‐066994
                Funded by: Helsefonden
                Award ID: 16‐B‐0176
                Funded by: Danish Heart Foundation
                Award ID: 16‐R107‐A6748‐22036
                Categories
                Original Research
                Original Research
                Epidemiology
                Custom metadata
                2.0
                jah32619
                October 2017
                Converter:WILEY_ML3GV2_TO_NLMPMC version:5.2.1 mode:remove_FC converted:24.10.2017

                Cardiovascular Medicine
                employment,epidemiology,myocardial infarction,outcome,prognosis,quality of life,work,cardiovascular disease,quality and outcomes,cost-effectiveness,rehabilitation

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