18
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Changes in Drosophila melanogaster Sleep-Wake Behavior Due to Lotus ( Nelumbo nucifera) Seed and Hwang Jeong ( Polygonatum sibiricum) Extracts

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          We evaluated the sleep enhancement activity of the medicinal herbs valerian ( Valeriana officinalis), jujube ( Ziziphus jujube), lotus seed ( Nelumbo nucifera), Gastrodia elata, Polygonatum sibiricum, and baekbokryung ( Poria cocos), which can relieve insomnia in a Drosophila model. Locomotor activity was measured in the Drosophila model to evaluate the sleep activity of Korean medicinal herbs traditionally used as sleep aids. The group treated with lotus seed extract showed less nocturnal activity. Treatment with 10 or 20 mg/mL of P. sibiricum significantly reduced nocturnal activity compared to the control group ( P<0.05). The activity and sleep bouts of fruit flies were significantly decreased by a high-dose treatment (10 mg/mL) of lotus or P. sibiricum extracts at night. Caffeine-treated Drosophila showed increased nocturnal activity and decreased total sleep time ( P<0.05). Flies receiving the 10 mg-doses of lotus seed or P. sibiricum extract showed significantly different nocturnal locomotor activity and total sleep time compared to caffeine-treated Drosophila. Lotus seed and P. sibiricum extracts are attractive and valuable sleep-potentiating nutraceuticals.

          Related collections

          Most cited references24

          • Record: found
          • Abstract: found
          • Article: not found

          Sedative hypnotics in older people with insomnia: meta-analysis of risks and benefits.

          To quantify and compare potential benefits (subjective reports of sleep variables) and risks (adverse events and morning-after psychomotor impairment) of short term treatment with sedative hypnotics in older people with insomnia. Medline, Embase, the Cochrane clinical trials database, PubMed, and PsychLit, 1966 to 2003; bibliographies of published reviews and meta-analyses; manufacturers of newer sedative hypnotics (zaleplon, zolpidem, zopiclone) regarding unpublished studies. Randomised controlled trials of any pharmacological treatment for insomnia for at least five consecutive nights in people aged 60 or over with insomnia and otherwise free of psychiatric or psychological disorders. 24 studies (involving 2417 participants) with extractable data met inclusion and exclusion criteria. Sleep quality improved (effect size 0.14, P 0.05), and reports of daytime fatigue were 3.82 times more common (1.88 to 7.80, P < 0.001) in people using any sedative compared with placebo. Improvements in sleep with sedative use are statistically significant, but the magnitude of effect is small. The increased risk of adverse events is statistically significant and potentially clinically relevant in older people at risk of falls and cognitive impairment. In people over 60, the benefits of these drugs may not justify the increased risk, particularly if the patient has additional risk factors for cognitive or psychomotor adverse events.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Clues to the functions of mammalian sleep.

            The functions of mammalian sleep remain unclear. Most theories suggest a role for non-rapid eye movement (NREM) sleep in energy conservation and in nervous system recuperation. Theories of REM sleep have suggested a role for this state in periodic brain activation during sleep, in localized recuperative processes and in emotional regulation. Across mammals, the amount and nature of sleep are correlated with age, body size and ecological variables, such as whether the animals live in a terrestrial or an aquatic environment, their diet and the safety of their sleeping site. Sleep may be an efficient time for the completion of a number of functions, but variations in sleep expression indicate that these functions may differ across species.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Herbal medicine for depression, anxiety and insomnia: a review of psychopharmacology and clinical evidence.

              Research in the area of herbal psychopharmacology has increased markedly over the past decades. To date however, a comprehensive review of herbal antidepressant, anxiolytic and hypnotic psychopharmacology and applications in depression, anxiety and insomnia has been absent. A search of MEDLINE (PubMed), CINAHL, PsycINFO, and the Cochrane Library databases was conducted (up to February 21st 2011) on commonly used psychotropic herbal medicines. A review of the literature was conducted to ascertain mechanisms of action of these botanicals, in addition to a systematic review of controlled clinical trials for treatment of mood, anxiety and sleep disorders, which are common comorbid psychiatric disorders. Specific emphasis was given to emerging phytomedicines. Analysis of evidence levels was conducted, as were effect sizes (Cohen's d) where data were available. Results provided evidence of a range of neurochemical, endocrinological, and epigenetic effects for 21 individual phytomedicines, which are detailed in this paper. Sixty six controlled studies were located involving eleven phytomedicines. Several of these provide a high level of evidence, such as Hypericum perforatum for major depression, and Piper methysticum for anxiety disorders. Several human clinical trials provide preliminary positive evidence of antidepressant effects (Echium amoenum, Crocus sativus, and Rhodiola rosea) and anxiolytic activity (Matricaria recutita, Ginkgo biloba, Passiflora incanata, E. amoenum, and Scutellaria lateriflora). Caution should however be taken when interpreting the results as many studies have not been replicated. Several herbal medicines with in vitro and in vivo evidence are currently unexplored in human studies, and along with use of emerging genetic technologies "herbomics", are areas of potential future research. Copyright © 2011 Elsevier B.V. All rights reserved.
                Bookmark

                Author and article information

                Journal
                Prev Nutr Food Sci
                Prev Nutr Food Sci
                Preventive Nutrition and Food Science
                The Korean Society of Food Science and Nutrition
                2287-1098
                2287-8602
                December 2017
                31 December 2017
                : 22
                : 4
                : 293-299
                Affiliations
                [1 ]Department of Integrated Biomedical and Life Sciences, Graduate School, Korea University, Seoul 02841, Korea
                [3 ]BK21Plus, College of Health Science, Korea University, Seoul 02841, Korea
                [2 ]Research and Development Center, Nong Shim Co., Ltd., Seoul 07057, Korea
                Author notes
                Correspondence to Hyung Joo Suh, Tel: +82-2-3290-5639, E-mail: suh1960@ 123456korea.ac.kr
                Article
                pnfs-22-293
                10.3746/pnf.2017.22.4.293
                5758092
                5d540036-abc1-4fb6-8ffd-3a15d1a25b8a
                Copyright © 2017 by The Korean Society of Food Science and Nutrition

                This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 18 September 2017
                : 31 October 2017
                Categories
                Articles

                nelumbo nucifera,polygonatum sibiricum,sleep,drosophila melanogaster

                Comments

                Comment on this article