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      Polycystic ovarian syndrome awareness among females in Palestine: a cross‑sectional study

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          Abstract

          Background and objectives:

          Polycystic Ovarian Syndrome (PCOS) is one of the most common endocrine disorders in fertile women. Limited data exists regarding Palestinian’s women awareness and understanding about PCOS. Therefore, we conducted this study to assess the knowledge, awareness and health-related practices of PCOS amongst the Palestinian women.

          Material and methods:

          Our cross-sectional study was conducted among the female population of Palestine, over the age of 18 years. The convenience sampling method was used to select the participants. A self-constructed questionnaire was used to interview regarding PCOS knowledge, awareness, causes, symptoms, prevention, complication and treatment. The date entry and statistical analysis was performed on STATA (V1).

          Results:

          A total of 1374 participants were randomly selected and invited to participate, most of them agreed, resulting in a response rate of 99.7%. The largest age group was 25–34 years (36.2%), followed by 18–24 years (33.5%). Awareness of the term PCOS had a mean score of 1.33 (SD = 0.74), indicating that most participants had heard of PCOS. Age was significantly associated with PCOS awareness (F = 3.67, P = 0.007), with participants aged 35–44 years having the highest mean awareness score (M = 1.87, SD = 0.64). Marital status also showed a significant association with awareness (F = 9.30, P = 0.001), as did residency (t = 3.30, P = 0.001). Educational level demonstrated a significant impact on awareness (F = 51.34, P = 0.001), and current work status was another significant factor affecting awareness (F = 52.22, P = 0.001).

          Conclusion:

          The level of PCOS awareness in the study sample was generally less substantial and inadequate in accuracy. As a result, increasing awareness of PCOS among females in the Palestine is crucial for promoting early diagnosis and improving patient outcomes.

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          Most cited references36

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          Diagnosis and Treatment of Polycystic Ovary Syndrome: An Endocrine Society Clinical Practice Guideline

          Objective: The aim was to formulate practice guidelines for the diagnosis and treatment of polycystic ovary syndrome (PCOS). Participants: An Endocrine Society-appointed Task Force of experts, a methodologist, and a medical writer developed the guideline. Evidence: This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to describe both the strength of recommendations and the quality of evidence. Consensus Process: One group meeting, several conference calls, and e-mail communications enabled consensus. Committees and members of The Endocrine Society and the European Society of Endocrinology reviewed and commented on preliminary drafts of these guidelines. Two systematic reviews were conducted to summarize supporting evidence. Conclusions: We suggest using the Rotterdam criteria for diagnosing PCOS (presence of two of the following criteria: androgen excess, ovulatory dysfunction, or polycystic ovaries). Establishing a diagnosis of PCOS is problematic in adolescents and menopausal women. Hyperandrogenism is central to the presentation in adolescents, whereas there is no consistent phenotype in postmenopausal women. Evaluation of women with PCOS should exclude alternate androgen-excess disorders and risk factors for endometrial cancer, mood disorders, obstructive sleep apnea, diabetes, and cardiovascular disease. Hormonal contraceptives are the first-line management for menstrual abnormalities and hirsutism/acne in PCOS. Clomiphene is currently the first-line therapy for infertility; metformin is beneficial for metabolic/glycemic abnormalities and for improving menstrual irregularities, but it has limited or no benefit in treating hirsutism, acne, or infertility. Hormonal contraceptives and metformin are the treatment options in adolescents with PCOS. The role of weight loss in improving PCOS status per se is uncertain, but lifestyle intervention is beneficial in overweight/obese patients for other health benefits. Thiazolidinediones have an unfavorable risk-benefit ratio overall, and statins require further study.
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            Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment With Emphasis on Adolescent Girls

            Abstract Polycystic ovary syndrome (PCOS) is a heterogeneous disorder characterized by hyperandrogenism and chronic anovulation. Depending on diagnostic criteria, 6% to 20% of reproductive aged women are affected. Symptoms of PCOS arise during the early pubertal years. Both normal female pubertal development and PCOS are characterized by irregular menstrual cycles, anovulation, and acne. Owing to the complicated interwoven pathophysiology, discerning the inciting causes is challenging. Most available clinical data communicate findings and outcomes in adult women. Whereas the Rotterdam criteria are accepted for adult women, different diagnostic criteria for PCOS in adolescent girls have been delineated. Diagnostic features for adolescent girls are menstrual irregularity, clinical hyperandrogenism, and/or hyperandrogenemia. Pelvic ultrasound findings are not needed for the diagnosis of PCOS in adolescent girls. Even before definitive diagnosis of PCOS, adolescents with clinical signs of androgen excess and oligomenorrhea/amenorrhea, features of PCOS, can be regarded as being “at risk for PCOS.” Management of both those at risk for PCOS and those with a confirmed PCOS diagnosis includes education, healthy lifestyle interventions, and therapeutic interventions targeting their symptoms. Interventions can include metformin, combined oral contraceptive pills, spironolactone, and local treatments for hirsutism and acne. In addition to ascertaining for associated comorbidities, management should also include regular follow-up visits and planned transition to adult care providers. Comprehensive knowledge regarding the pathogenesis of PCOS will enable earlier identification of girls with high propensity to develop PCOS. Timely implementation of individualized therapeutic interventions will improve overall management of PCOS during adolescence, prevent associated comorbidities, and improve quality of life.
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              The Prevalence of Polycystic Ovary Syndrome: A Brief Systematic Review

              Background: Polycystic ovary syndrome (PCOS), the major endocrinopathy among reproductive-aged women, is not yet perceived as an important health problem in the world. It affects 4%–20% of women of reproductive age worldwide. The prevalence, diagnosis, etiology, management, clinical practices, psychological issues, and prevention are some of the most confusing aspects associated with PCOS. Aim: The exact prevalence figures regarding PCOS are limited and unclear. The aim of this review is to summarize comprehensively the current knowledge on the prevalence of PCOS. Materials and Methods: Literature search was performed through PubMed, ScienceDirect, Cochrane Library, and Google Scholar (up to December 2019). All relevant articles published in English language were identified following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Results: Our analysis yielded 27 surveys with a pooled mean prevalence of 21.27% using different diagnostic criteria. The proportion of women with PCOS also increased in the last decade. Conclusion: The current review summarizes and interprets the results of all published prevalence studies and highlights the burden of the syndrome, thereby supporting early identification and prevention of PCOS in order to reverse the persistent upward trend of prevalence.

                Author and article information

                Contributors
                Journal
                Ann Med Surg (Lond)
                Ann Med Surg (Lond)
                MS9
                Annals of Medicine and Surgery
                Lippincott Williams & Wilkins (Hagerstown, MD )
                2049-0801
                April 2025
                27 March 2025
                : 87
                : 4
                : 1883-1892
                Affiliations
                [a ]Faculty of Medicine, Al-Quds University, Jerusalem, Palestine
                [b ]Faculty of Medicine, Dow University of Health Sciences, Karachi, Pakistan
                [c ]Surgical Research Section, Department of Surgery, Hamad Medical Corporation, Doha, Qatar
                [d ]Department of Public Health, College of Health Sciences, QU-Health, Qatar University, Doha, Qatar
                [e ]Ayub Medical College, Abbottabad, Pakistan
                [f ]Peshawar Medical College, Ripaha International University, Pakistan
                [g ]Department of Obstetrics and Gynecology, Istishari Arab Hospitals, Ramallah, Palestine
                Author notes
                [* ]Corresponding author. Address: Faculty of Medicine, Al-Quds University, Ramallah, Palestine, Jerusalem, Palestine. Tel: +972593656364. Fax: 02-2986311. E-mail: oadi.shrateh@ 123456students.alquds.edu (O. N. Shrateh).
                Article
                AMSU-D-24-02559 00020
                10.1097/MS9.0000000000003057
                11981444
                40212203
                5d5707b0-fbe4-4ba5-94cf-6b89ba1bf125
                Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc.

                This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

                History
                : 07 December 2024
                : 02 February 2025
                Categories
                Cross-Sectional Study
                Custom metadata
                TRUE

                hormonal imbalance,hyperandrogenism,infertility,ovarian disorder,polycystic ovarian syndrome

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