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      Association between endoplasmic reticulum stress and risk factors of diabetic retinopathy

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          Abstract

          Diabetic retinopathy (DR) is one of the most common and challenging ocular complications of diabetes mellitus. As a chronic, progressive ocular disease that poses a serious threat to vision, DR has gradually become a leading cause of blindness worldwide. Emerging evidence points to an important role of endoplasmic reticulum (ER) stress in not only maintaining the steady-state equilibrium in the body, but also in intracellular synthesis, protein folding, and other essential functions. Recent studies have demonstrated clear associations between ER stress-related physiological functions and the pathogenesis of DR. When cells are stimulated by external stimuli, UPR pathway is activated firstly to protect it. However, long-term harmful factors can induce ER stress. which interferes with the physiological metabolism of retinal cells and participates in the occurrence of DR via the ATF6 pathway, PERK pathway and IRE1 pathway. At present, ER stress blocker is expected to become a new anti-DR therapy. Thus, understanding the relationship between ER stress and DR will help to develop new effective preventative treatments. In this review, we summarize the risk factors of DR pathogenesis induced by ER stress toward revealing potentially new therapeutic targets.

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          Author and article information

          Journal
          Int J Ophthalmol
          Int J Ophthalmol
          IJO
          International Journal of Ophthalmology
          International Journal of Ophthalmology Press
          2222-3959
          2227-4898
          18 October 2018
          2018
          : 11
          : 10
          : 1704-1710
          Affiliations
          [1] Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
          Author notes
          Correspondence to: Guang-Ying Zheng. Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, No.1 East Jianshe Road, Zhengzhou 450052, Henan Province, China. zzzgy@ 123456zzu.edu.cn
          Article
          PMC6192950 PMC6192950 6192950 ijo-11-10-1704
          10.18240/ijo.2018.10.20
          6192950
          30364130
          5d5aaa28-aa2e-471d-9d2d-779240c41471
          International Journal of Ophthalmology Press
          History
          : 27 December 2017
          : 12 July 2018
          Categories
          Review

          vascular endothelial growth factor,endoplasmic reticulum stress,diabetic retinopathy,unfolded protein response

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