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      • Record: found
      • Abstract: found
      • Article: found

      Eccrine Angiomatous Hamartoma: A Clinicopathological Study of 26 Cases

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          Abstract

          Background: Eccrine angiomatous hamartoma (EAH) is a rare benign cutaneous tumor characterized by the proliferation of eccrine glands and capillaries. Objective: The aim of this study was to summarize the clinicopathological characteristics of EAH. Methods: A retrospective chart review was performed on all patients diagnosed with EAH from 1977 to 2012 in the Union Hospital, Wuhan, P.R. China, and the clinicopathological features were compared with the cases reported in the literature. Results: A total of 26 patients with EAH were identified. The male:female ratio was 1.2:1. EAH most commonly presents as a solitary (80.8%) plaque (50.0%) on the lower extremities (61.5%). Most patients presented with hyperhidrosis localizing to the lesion. Although most patients did not have major pain or anatomic deformity, one patient had severe pain as well as difficulty walking and moving, necessitating leg amputation. The histopathological findings showed typical features of EAH. Conclusion: EAH is a rare but characteristically benign skin hamartomatous condition. In rare occasions it can be associated with severe structural and functional impairment.

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          Eccrine angiomatous hamartoma.

          N Pride, B. Tyler, Michelle Pelle (2002)
          Four patients with eccrine angiomatous hamartoma are described. Blue-purple color, enlarging size, location on an extremity, pain, and hypertrichosis were common features and aided differentiation from other vascular anomalies and hamartomas of childhood. None of our patients experienced lesional hyperhidrosis, and simple excision alleviated pain.
          Article 0 comments Cited 11 times – based on 0 reviews     Review now
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            Congenital eccrine angiomatous hamartoma.

            Emilio A. Martinez, V A Alegre, O. Sanmartín … (1992)
            A case of congenital eccrine angiomatous hamartoma of the foot in a three-month-old girl is presented. Eccrine angiomatous hamartoma is a benign tumoral lesion that combines the proliferation of multiple benign eccrine structures and angiomatous channels. We review the literature on the subject.
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              Eccrine angiomatous hamartoma (nevus): immunohistochemical findings and review of the literature.

              R Sulica, G Kao, Virginia I Sulica … (1994)
              Eccrine angiomatous hamartoma (nevus) is a rare form of congenital tumorous malformation with proliferation of eccrine secretory coils and ducts, surrounding capillary angiomatous channels and occasionally other minor elements. To date, there have been only about 24 cases reported in the literature. We report an additional case with more detailed description of the microscopic findings, including immunohistochemical observations. The patient was a 28-year-old female who presented with painless, flesh- to reddish brown-colored, violaceous or bluish subcutaneous nodules on the extremities and trunk. The tumors did not show sweating following exertion. The histologic features were comparable to the previously reported cases. The hamartomatous eccrine sweat glands and ducts and a few apocrine glands demonstrated qualitatively diminished antigens commonly found in the eccrine sweat apparatuses, such as carcinoembryonic antigen (CEA) and S-100 protein. The findings of CD34, CD44, human nerve growth factor receptor and Ulex europaeus antigens have not been previously reported. The histologic features suggested a "hamartomatous" growth rather than a true neoplastic process.
              Article 0 comments Cited 8 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (publisher-id): DRM
                Journal ID (nlm-ta): Dermatology
                Journal ID (doi): 10.1159/issn.1018-8665
                Title: Dermatology
                Publisher: S. Karger AG
                ISSN (Print): 1018-8665
                ISSN (Electronic): 1421-9832
                Publication date Subscription-year: 2015
                Publication date (Print): June 2015
                Publication date (Electronic): 14 April 2015
                Volume: 231
                Issue: 1
                Pages: 63-69
                Affiliations
                aDepartment of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, bDepartment of Dermatology, Zhongshan Hospital, and cDepartment of Dermatology, The First Hospital of Wuhan City, Wuhan, P.R. China; dDepartment of Dermatology and Skin Science, University of British Columbia, Vancouver, B.C., Canada
                Author notes
                *Changzheng Huang, Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei (P.R. China), E-Mail hcz0501@126.com, Youwen Zhou, Department of Dermatology and Skin Science, University of British Columbia, 835 West 10th Ave, Vancouver, BC V5Z 4E8 (Canada), E-Mail ywzhou@interchange.ubc.ca
                Article
                Publisher ID: 381421 Other ID: Dermatology 2015;231:63-69
                DOI: 10.1159/000381421
                PubMed ID: 25895513
                SO-VID: 5d67894b-9fd3-488f-945a-ad539b3d079e
                Copyright © © 2015 S. Karger AG, Basel
                License:

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                History
                Date received : 05 January 2015
                Date accepted : 04 March 2015
                Page count
                Figures: 2, Tables: 2, References: 29, Pages: 7
                Categories
                Subject: Original Paper

                ScienceOpen disciplines: Oncology & Radiotherapy,Pathology,Surgery,Dermatology,Pharmacology & Pharmaceutical medicine
                Keywords: Eccrine sweat gland,Eccrine tumor,Eccrine angiomatous hamartoma
                Data availability:
                ScienceOpen disciplines: Oncology & Radiotherapy, Pathology, Surgery, Dermatology, Pharmacology & Pharmaceutical medicine
                Keywords: Eccrine sweat gland, Eccrine tumor, Eccrine angiomatous hamartoma

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