1. Introduction
An international scientific conference was sponsored by the journal Sensors under
the patronage of the University of Basel. The 4th edition of the International Symposium
on Sensor Science (I3S2015) ran from 13 to 15 July 2015 in Basel, Switzerland. It
comprised five plenary sessions and one morning with three parallel sessions. The
conference covered the most exciting aspects and the latest developments in sensor
science. The conference dinner took place on the second evening of the conference.
The I3S2015 brought together 170 participants from 40 different countries.
The next edition of the I3S2016 conference will be held in Durham, NH, USA, 17–22
July 2016.
2. Session 1: Sensor Breakthroughs
Session Chair: Debbie G. Senesky
The first session of the symposium provided an update on recent sensor breakthroughs.
The keynote speaker, R. Horisberger, impressed the attendees with a detailed description
of the use of supreme sensing to answer the ultimate questions of physics. C. Fattinger
presented the use of focal molography to realize coherent detection of biomolecular
interactions for a variety of biological applications. V.M. Mirsky presented the creation
of ultrasensitive sensors by leveraging surface plasmon resonance (SPR). L.S. Marcus
discussed trace gas sensing and standoff detection of solid materials using photoacoustic
spectroscopy-based sensor platforms. T. Wagner reviewed the progress in creating a
fully-integrated (bio-)chemical sensor platform using light-addressable potentiometric
sensors. The session closed with a talk by E. Katz on binary operating biosensors
based on biocomputing systems. It was a lively session with active discussions that
provided new insights for the sensor science community.
3. Session 2: Biosensors
Session Chair: Michael J. Schöning
This session has been focussing on recent developments in the field of different types
of biosensors as well as some nanosensor-based applications. Besides physical sensors
and chemical sensors, biosensors belong to the third class of sensing devices with
strongly increasing interest within the last 20 years. There are even several (worldwide)
conferences purely addressing this topic year by year. The biosensors session offered
a keynote lecture, given by H. Ju (China), two invited lectures by A. Star (USA) and
S. Kolev (Australia), and five selected presentations by T. Yoetz (Isreal), L. Francis
(Belgium), G. Zabow (USA), A. Poghossian (Germany) and M. Packirisamy (Canada).
All presentations have been driven by application-oriented research activities―Coming
from pure “academic” research into the “real” market: H. Ju, for instance, gave an
overall survey on a multitude of possible signal amplification strategies for biosensing,
also covering important nano-aspects in optimizing intrinsic biosensor features. A.
Star and S. Kolev discussed on the one hand different chemical and biological sensor
approaches with carbon nanostructures, and on the other hand, easy to fabricate and
cheap, disposable paper-based microfluidic sensors for environmental monitoring and
analysis. Further aspects in this session have been covering biosensors for the detection
of proteins by means of nanostructured integrated optofluidic chips (M. Packirisamy),
micro- to nanoscale magnetic-type (bio)sensors offering opportunities similar to those
of fluorescence-type optical biosensors but operating at radio-frequency wavelengths
(G. Zabow), semiconductor-based field-effect biosensors for the label-free detection
of single- and double-stranded DNA molecules (A. Poghossian), amperometric biosensors
utilizing bacteria for the screening of cytochrome P450 inhibitors (T. Yoetz) and
an integrated capacitive biosensor array for the selective and real-time detection
of whole bacterial cells with a high sensitivity.
In conclusion, it was a very active session including very fruitful discussions. All
main transducer principles of biosensors were presented, i.e., there was a representative
cross section of running biosensor activities from all over the world.
4. Session 3: Chemical Sensors
Session Chair: Peter C. Hauser
The session on chemical sensors was highly diverse in terms of sensing principles,
as well as applications. T. Yoshinobu, the keynote lecturer, showed that it is possible
to obtain spatially-resolved measurements with an array of potentiometric sensors,
which can be individually addressed with a light beam. D. Diamond stressed that chemical
sensors often are best employed as part of an analytical system based on microfluidics.
R. Seitz discussed optical sensing of metals with membranes containing fluorophores.
K. Bonnot reported on the calorimetric determination of explosives, i.e., methods
based on their combustion in porous materials. The second speaker from Japan, K. Mitsubayashi,
brought us back to spatially-resolved measurements, this time on the determination
of ethanol vapors (e.g., in exhaled breath) by picturing the chemiluminescence obtained
on a mesh impregnated with the reaction mixture. J. Stiens discussed the use of THz
waves in sensing, while E. Gallegos-Arellano employed the more conventional IR range
for the determination of CO and CO2. The last speaker, F. Josse, described the employment
of surface acoustic waves for the determination of aromatic compunds such as benzene
using appropriate membranes with affinity to the analysts. All in all, it was a very
satisfying session with something to hold everybody’s interest.
5. Session 4: Extreme Sensing
Session Chair: Roland Moser
This session offered a series of amazing accomplishments of sensing in extreme environments
or sensing with extreme performance. The first talk given by D.G. Senesky (Stanford)
covered micro- and nano-scale sensors for extreme harsh environments: By using wide-bandgap
semiconductors, such as silicon carbide or gallium nitride, complete sensor systems
can be built that can reliably acquire and transmit data at ambient temperatures of
a scorching 600 °C or even more. This exciting opening speech of the session was followed
by M.J. Schöning’s (FH Aachen) description of thin-film sensors for monitoring aseptic
food processes. This requires extremely robust sensor types withstanding the highly-corrosive
effects of the employed potent sterilization gas hydrogen peroxide (H2O2). The next
presentation on a high-sensitivity NO, NO2 and NH3 high electron mobility transistor
(HEMT)-based sensor for diesel exhaust systems was contributed by Y. Halfaya (Georgia-Tech
CRNS). She described a particularly robust sensor solution based on HEMT devices fabricated
with group III-nitride materials, offering a high resistance to corrosion, humidity
and high temperatures. T. Laroche (frecnsys SAS) talked about surface-acoustic wave
sensors on Langasite substrates for high temperature measurements exceeding 700 °C.
He put particular emphasis on explaining a comprehensive model for understanding and
computing the electrical response of SAW devices. X. Zhang (Beijing University of
Science and Technology) described a collection of new approaches for microRNA detection.
All of these techniques have the potential to measure microRNA in their typical low
concentration with high sensitivity and high specificity. A. Ionescu (EPFL) contributed
an intriguing talk about how the sensitivity and energy efficiency limits for integrated
transducers can be broken with a novel type of Tunnel-FET sensor. These devices offer
extreme electrostatic sensitivity of their quantum mechanical band-to-band tunneling
current, enabling a future generation of biosensors, gas sensors and imagers operating
at voltages as low as 100 mV with unprecedented energy efficiency. The concluding
presentation by J. Leuthold (ETHZ) described new ways of photonic probing with plasmonic
devices. This culminated in the impressive description of an ultra-miniature Mach–Zehnder
modulator of only 10 µm in length.
6. Three Parallel Sessions
6.1. Session 5.1: Photonic Sensing
Session Chair: Hans Peter Herzig
The main part of the session was focused on photonic sensing in the mid‐infrared (mid-IR)
wavelength range. This activity is strongly driven by the availability of broadly
tunable sources, like difference frequency generation (DFG) and external cavity quantum
cascade lasers (EC‐QCLs) or the most recent development of diode‐pumped lead salt
vertical external cavity surface emitting lasers (VECSELs). The mid-IR is an emerging
and important new domain for frontier research. Most complex molecules, such as those
found in food, tissue or catalytic compounds, have vibrational spectra in the mid-IR,
thus identifiable through mid-IR spectroscopy. Furthermore, the fundamental absorption
bands of gas molecules are located in the mid-IR.
A main obstacle for the exploitation of the mid-IR optical window has been a lack
of sensitive mid-IR detectors/imaging devices working at room temperature. The first
presentation given by C. Pedersen, DTU Fotonik (DK) suggested an upconversion technology
as a route to circumvent the unavoidable “dark noise” associated with standard mid-IR
detectors, thus opening a door to mid-IR, room temperature single-photon spectral
imaging and hyper spectral imaging.
Silicon on insulator Vernier devices for high performance photonic sensing in the
near- and mid-IR have been presented by V.M.N Passsaro, Politecnico di Bari (I). The
Vernier effect is widely used in refractive index sensors.
IR-wavelength quantum dot-based sensing has been discussed in the third talk by V.
Woods, ETH Zurich (CH). Composite semiconductors manufactured by the low-cost, solution-based
deposition of colloidally-synthesized semiconductor quantum dots (QDs) are of growing
interest.
Laser-based sensing offers several advantages, such as high sensitivity and specificity,
large dynamic range, multi-component capability and a lack of pretreatment or preconcentration
requirements. The basic principle and various experimental setups have been illustrated
by M.W. Sigrist, ETH Zurich (CH).
The last three presentations discussed mainly photonic nanostructures and single-photon
detection. Films with dimensions smaller than the electron mean free path are essential
to measure large resistance changes due to small alterations in thickness or the close
proximity of charged species. Simultaneous electrical and plasmonic sensing with gold
nanostructures has been demonstrated by R. Tiefenauer, ETH Zurich (CH), using ultrathin
gold films with incorporated nanoholes.
Zinc oxide nanostructures have received broad attention due to their distinguished
performance in electronics, optics, gas sensing and piezoelectronics. The presentation
of S. Rackauskas, University of Caminas (BR), introduced Zinc oxide tetrapod (ZnO-T)
as one of these structures, which consists of four nanowires and is especially interesting
for its simple synthesis. ZnO-T is an excellent material for UV sensors.
For many optical sensing and communication applications, including LiDAR, single-molecule
spectroscopy and quantum cryptography, detectors with sensitivity at the single-photon
level are required. Therefore, the session ended with the presentation of A. Fiore,
Eindhoven University of Technology (NL), about sensing at the quantum limit, which
means at the level of photons. A detector technology based on arrays of superconducting
nanowires allows the measurement of the photon number in a pulse in the 1 to 24 photon
range.
6.2. Session 5.2: Remote and Micropower Sensors
Session Chair: Assefa M. Melesse
The first keynote presentation was by L. Reindl on power supply for wireless sensor
or actuator systems. In this presentation by L. Reindl, several concepts for an alternative
power supply of wireless sensor or actuator systems were discussed. The advantages
of actuators over the ordinary power sources like batteries were presented. The speaker
presented an extensive sources of information and direction of the research on wireless
sensors or actuators.
The next presentation was by A.M. Melesse from Florida International University on
sensors and remote sensing applications for understanding coastal and wetland processes.
The use of satellite data from Landsat, MoDIS and SeaWIFS was presented in mapping
and modeling spatial evapotranspiration (ET), wetland vegetation and also algal blooms
before and after tropical storm activities. The use of remote sensing in modeling
spatial ET for wetland restoration evaluation was also presented.
The remaining three presenters were from the Polish Academy of Sciences and their
research were related and focused on TDR measurements.
A. Szypłowska’s talk was on the determination of complex dielectric permittivity spectra
from the analysis of electrical signal reflection in transmission lines of various
lengths. The speaker stressed that determination of the complex dielectric permittivity
frequency spectrum should increase the accuracy of in-situ soil moisture measurements,
as well as provide information about other soil properties.
A. Wilczek from the Polish Academy of Sciences presented on the impact of the TDR
pulse width on the reflection amplitude and its dependence on soil dielectric loss
and electrical conductivity. The presented research describes the application of a
needle TDR pulse of variable width to measure soil dielectric properties.
M. Kafarski also talked about the porous corundum plate sensor for atmospheric water
deposits’ TDR measurements. In this presentation, the speaker indicated that of the
research was to test the sensor for the atmospheric water deposits intensity measurements
and to define its measuring range and detection level.
6.3. Session 5.3: Neurosensors
Session Chair: Patricia A. Broderick
Neurosensors 5.3 was a lively session, filled with discussion, back and forth questions
and answers, and each topic was presented in detail with great aplomb. Each topic
was meaningful to micromachines, microelectrodes and nanobiosensors for clinical and
preclinical science and medicine. The unique and precise work that was presented during
this session was truly translational and, indeed, remarkable.
S. Lacour holds the Bertarelli Foundation Chair in Neuroprosthetic Technology at the
School of Engineering at the Ecole Polytechnique Fédérale de Lausanne. She received
her PhD in Electrical Engineering from INSA de Lyon, France, and completed postdoctoral
research at Princeton University (USA) and the University of Cambridge, U.K. S. Lacour
was the first speaker. Stephanie gave the first keynote speech of the session for
one hour. Her presentation was, soft transducers to communicate with the nervous system.
Her research focuses on the materials, technology and integration of soft bioelectronic
interfaces, including artificial skin, ultra-compliant neural electrodes for in vitro
platforms, as well as in vivo implants. In this speech, there was a description of
microelectrode arrays implanted on the surface of the brain and/or within the neural
tissue under the brain membranes that surround the brain, under the skull. Stephanie
and her group have developed elastic-type bioelectronic interfaces that allow the
prosthesis to become more facile, which is a major advance in providing non-ambulating
patients the ability to walk. Although this important work is still in progress in
animals, the promise of new materials that are more elastic and yet biocompatible
provides hope for the paralyzed patient. S. Lacour showed a video that allowed an
animal to walk. Although the animal was still restrained, the video was impressive!
Enabling a paralyzed patient to walk is ground breaking research, and the work is
commendable.
P.A. Broderick gave the second keynote address for one hour. The title was nanobioimaging:
personalized medicine in real life is here. Nanotechnology Meets the Brain. P.A. Broderick
completed her PhD degree in pharmacology at St. John’s University, College of Arts
and Sciences, completed her postdoctoral fellowship at the Albert Einstein College
of Medicine/Montefiore Hosp. and completed her Research Associate Position at Cornell
University, Department of Neurology, NY. Patricia is a tenured full Professor at the
City University of New York School of Medicine and NYU Medical Center and Comprehensive
Epilepsy Center. She is Professor at the CUNY Graduate Center in the Department of
Biology and Course Director in Pharmacology for the Physicians Assistants Program
at the City University of New York School of Medicine, in affiliation with the Harlem
Hospital Center, NY, USA. Patricia is widely known for her innovative pioneering work
in inventing the BRODERICK PROBE® nanobiosensor for which she has obtained worldwide
recognition as an industry expert. This nanobiosensor images chemical and biologic
substances within a temporal resolution as low as nanoseconds in real time, in vivo,
in vitro and in situ in the intact living brain as a subject is moving about freely.
Patricia presented translational work on using this nanobiosensor in epilepsy patients
and animals with Parkinson’s disease. Biomarkers for these neurodegenerative brain
disorders were revealed and compared to image profiles for brain neurotransmitters
in non-diseased parts of brain actually in the same subject, enabling personalized
medicine to become a reality clinically. The technology marks the advent of a completely
different way to see “how the brain works” and “how to treat the brain that does not
work”.
C.P. Brändli provided the next speech for one half hour on Neuro-Inspired, Event-Based
Vision Sensors. C.P. Brändli received his BSc and MSc in interdisciplinary sciences
(focus neuroscience and physics) from the ETH Zurich. He conducted his PhD in the
lab of T. Delbruck at the Institute of Neuroinformatics, UZH/ETHZ, in Zurich, on the
topic of event-based vision sensors. C.P. Brändli presented his work on sensors embedded
in a micromachine, and the quantum physics was exciting to follow. C.P. Brändli also
presented his work on vision in the retina based on his micromachine, and he is heavily
involved in working with Silicon Valley to move his inventions forward. His startup
company is “Insightness”, which he co-founded.
F. Picollo gave the fourth speech on diamond-based electrochemical sensor: a multi
electrode array for simultaneous detection of quantal exocytic events from neuroendocrine
cells. This speech again brought in clinical research showing how graphite sensors,
embedded in diamond, can see fluids released from endocrine cells in quantum amounts
seeping out of cells. His background is described as PhD in Material Science from
the University of Torino in 2011 with a thesis titled “Single crystal diamond micro-fabrication
by means of ion beams”. He studied the effects of ion implantation in diamond in order
to induce the graphitization of the crystal. He applied this process in order to realize
a prototype of a particle detector and a prototype of a biosensor in which buried
graphitic structures are the active electrodes. After, he held a post-doc position
at the Solid State Physics group of the University of Torino, where his activity was
focused on the development of diamond-based cellular sensors. From 2014, he has been
the principal investigator of a project called DiNaMo (Diamond Nano Modification)
of the National Institute of Nuclear Physics (INFN) devoted to improve the spatial
resolution of high energy (MeV) ion beam lithography. F. Picollo’s speech also brought
about, with the chair and participants, interesting electrochemical principles in
which the differences between the allotropes of carbon and their properties affect
signals. The chair advised that there might be a signal for adenosine triphosphate
in one of the electrochemical signals presented. Suggestions were given to discover
a new sensor from this work.
Y. Leblebici gave the final speech to round out this great session. His title was:
3D microelectrode arrays for Neuro-Sensing: Read-out circuit design and hybrid 3D
integration. Y. Leblebici received his PhD degree in electrical and computer engineering
from the University of Illinois, Urbana-Champaign (UIUC), in 1990. Since 2002, he
has been a Chair Professor at the Swiss Federal Institute of Technology in Lausanne
(EPFL) and Director of the Microelectronic Systems Laboratory. His research interests
include design of high-speed CMOS digital and mixed-signal integrated circuits, computer-aided
design of VLSI systems, intelligent sensor interfaces, modeling and simulation of
semiconductor devices, as well as VLSI reliability analysis. He is the coauthor of
six textbooks, as well as more than 300 articles published in various journals and
conferences. He has been a Fellow of IEEE since 2010, and he has been elected as Distinguished
Lecturer of the IEEE Circuits and Systems Society for 2010 to 2011. This speech was
related to multi-platform electronics to channel several hundred signals at once.
It was extremely interesting and necessary for biosensors, such as P.A.
Broderick’s nanobiosensors for epilepsy patients. There was, however, a feisty debate
on the state of the art in this discussed electronic platform. C. Brandli thought
that this type of complex platform is already available, and Y. Leblebici wholeheartedly
disagreed.
The session chair would like to thank MDPI in Basel, Switzerland, and Beijing, China,
for this fabulous opportunity!
7. Session 6: Single-Chip Sensors and Sensor Networks
Patrick Thomas Eugster
This session combined presentations describing ultra-miniature sensor systems realized
as single-chip solutions and complete networks of miniaturized sensor nodes. In the
first talk of this session, A. de Mello (ETHZ) introduced droplet-based microfluidic
devices, paving the way towards ultra-high throughput experimentation. There is a
rapidly growing interest in such lab-on-a-chip technology, in large part driven by
concomitant advances in the areas of genomics, proteomics, cellomics, drug discovery,
high-throughput screening and diagnostics, with a clearly defined need to perform
rapid measurements on ultra-small sample volumes. C. Schönenberger (University of
Basel) described silicon-nanowire ion-sensitive field-effect transistors, providing
for highly-sensitive pH detectors. It is shown how a platform of ion-sensitive sensors
can be realized, consisting of differently-functionalized wires, capable of sensing
different ions (H+, K+, Cl−, Ca2+) with certain selectivity. The following talk by
D. Sallin (EPFL) introduced a CMOS-compatible photodetector with intrinsic light-to-time
conversion for low-light applications, such as bioluminescence. Measurements demonstrate
impressive performances down to an intensity of 10−8 W/cm2 and below. The talk on
smart image sensors for metrology applications was contributed by a representative
of E. Franzi (CSEM). A VLSI implementation of the author’s spaceCoder technology was
described, which is a complete vision-based chip specifically tailored for metrology
applications. The session part on sensor networks was introduced by P. Eugster (Purdue
University), who explained a possible progression towards a robust Internet of Things
in the case of wireless sensor networks. The challenge is to provide the development
of debugging and monitoring solutions for a reliable and secure IoT, including techniques
for gathering runtime information on individual sensor nodes’ executions and interactions
among nodes, as well as for efficiently compressing such information. The next presentation
was given by T. Watteyne (UC Berkeley), describing the building of the industrial
Internet of Things by transforming the Smart Dust concept into the 6TiSCH standard.
Particular attention was given to a concise explanation of IETF 6TiSCH, the working
group that combines the performance of industrial low-power wireless with the ease
of use of IPv6. C.-Y. Wen (National Chung Hsing University) explained an energy-efficient
scheduling method with compressed sensing for distributed target tracking. In this
method, a two-level hierarchical wireless sensor network is designed for cooperative
target tracking via compressing information. The final contribution by Jean-Dominique
Decotignie (CSEM) summarized his experience and lessons learned in designing various
wireless sensor networks for real-time operation with low power consumption, realized,
for example, on glaciers, in buildings, on trains and on planes. Among other things,
the author dispelled seven myths (e.g., “signal strength is a function of distance”)
about wireless sensor network design.