- Record: found
- Abstract: not found
- Article: not found
Carvedilol, a new β-adrenoceptor antagonist and vasodilator antihypertensive drug, inhibits superoxide release from human neutrophils
April 1992
April 1992
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Carvedilol produced a dose-dependent inhibition of superoxide (O2-) release from human
neutrophils (PMNs) (IC50 = 28 microM) and scavenged O2- generated during dihydroxyfumaric
acid (DHF) autooxidation (IC50 = 41 microM). Other beta-blockers, such as celiprolol,
labetalol and atenolol, or the antioxidant, 'lazaroid', U74500A had no effect on O2-
either released from PMNs or generated during DHF autooxidation. Propranolol, at 0.3
mM, inhibited O2- release from PMNs (73%) but failed to scavenge O2- generated from
DHF. The novel free radical-scavenging effect of carvedilol may contribute to the
cardioprotective activity of the compound.