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Matrix solid-phase dispersion
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Abstract
Matrix solid-phase dispersion (MSPD) is a patented process, first reported in 1989,
for conducting simultaneous disruption and extraction of solid and semi-solid samples.
MSPD permits complete fractionation of the sample matrix components as well as the
ability to selectively elute a single compound or several classes of compounds from
the same sample. The method has been applied to the isolation of drugs in food animal
tissues but has also found wide application in the analysis of herbicides, pesticides
and pollutants from animal tissues, fruits, vegetables and other matrices. The present
article provides a review of MSPD applications in these and related fields and discusses
the factors known to affect MSPD methods. Both the practical and theoretical aspects
of MSPD are also presented.