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      Insertion/Deletion Plasminogen Activator Inhibitor 1 and Insertion/Deletion Angiotensin-Converting Enzyme Gene Polymorphisms in Diabetic Retinopathy in Type 2 Diabetes

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          In an association study, the relationship between the insertion/deletion (I/D) plasminogen activator inhibitor 1 (PAI-1) gene polymorphism or the I/D angiotensin 1-converting enzyme (ACE) gene polymorphism and the development of diabetic retinopathy in patients with type 2 diabetes was investigated. One hundred and twenty-four subjects with type 2 diabetes and diabetic retinopathy were compared to 80 diabetic subjects without retinopathy with diabetes of a duration of more than 10 years. The PAI-1 gene distribution and ACE gene distribution in patients with diabetic retinopathy (4G4G 31.4%, 4G5G 46.8%, 5G5G 21.8%; DD 26.6%, ID 50.8%, II 22.6%) were not significantly different from those of diabetic subjects without retinopathy (4G4G 31.3%, 4G5G 50%, 5G5G 18.7%; DD 31.3%, ID 40%, II 28.7%). Neither the 4G/5G PAI-1 gene polymorphism nor the I/D ACE gene polymorphism contributed to the genetic susceptibility to diabetic retinopathy, either non-proliferative, proliferative or severe proliferative diabetic retinopathy, i.e. visual acuity of 0.1 or less in the better eye, in a group of Caucasian subjects with type 2 diabetes.

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          Cell-associated plasminogen activation: regulation and physiological functions.

           O Saksela,  G Rifkin (1987)

            Author and article information

            S. Karger AG
            June 2003
            04 April 2003
            : 217
            : 3
            : 219-224
            aEye Clinic, and bDivision of Medical Genetics, Department of Obstetrics and Gynaecology, University Medical Centre Ljubljana, and cInstitute of Histology and Embryology, Medical Faculty Ljubljana, University of Ljubljana, Ljubljana, Slovenia
            68975 Ophthalmologica 2003;217:219–224
            © 2003 S. Karger AG, Basel

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            Page count
            Tables: 3, References: 34, Pages: 6
            Original Paper


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