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      Recurrence Risk of Renal Cell Carcinoma Lingers Even Decades After Nephrectomy

      case-report
      Author(s): 1 , 1 , 1 , , 2
      Editor(s): ,
      Publication date (Electronic, pub):
      Publication date (Electronic, collection):
      Journal: Cureus
      Publisher: Cureus
      Keywords: renal cell carcinoma, renal cell metastasis, metastasis, lung nodule, renal neoplasm

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          Abstract

          Renal cell carcinoma (RCC) is a common malignancy in elderly males. Metastatic spread of this cancer is not an uncommon occurrence, even after nephrectomy. Lung, bone, liver, and brain are the most frequently involved sites. Such a type of presentation mostly occurs within five years after nephrectomy however, cases have been reported later as well. Here, we report a case of metastatic renal cell carcinoma that presented in the form of a lung growth 28 years after nephrectomy. This highlights the importance to consider relapsed metastatic renal cancer in the differential, even decades after its surgical removal.

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          Surveillance strategies for renal cell carcinoma patients following nephrectomy.

          Carol Lam, Arie S. Belldegrun, Arnold I. Chin … (2005)
          Renal cell carcinoma (RCC) is the most lethal of urologic malignancies, accounting for an estimated 36,000 new cases of carcinoma and 12,000 deaths in 2005. Nephrectomy is the usual treatment; however, after nephrectomy, RCC recurs in 20% to 40% of patients with clinically localized disease. A consensus surveillance protocol does not exist for follow-up of RCC after nephrectomy. In this article, available protocols are reviewed with a goal of developing an evidence-based system including the prognostic factors for recurrent disease, chronology and sites of recurrence, available treatment options if recurrent disease is found, and modalities of diagnostic testing available to urologists. New surveillance recommendations are presented based on prognostic factors as well as the University of California, Los Angeles Integrated Staging System for RCC.
          Article 0 comments Cited 57 times – based on 0 reviews     Review now
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            Evaluation of the National Comprehensive Cancer Network and American Urological Association Renal Cell Carcinoma Surveillance Guidelines

            Suzanne Stewart, R Thompson, Sarah Psutka … (2014)
            The National Comprehensive Cancer Network (NCCN) and American Urological Association (AUA) provide guidelines for surveillance after surgery for renal cell carcinoma (RCC). Herein, we assess the ability of the guidelines to capture RCC recurrences and determine the duration of surveillance required to capture 90%, 95%, and 100% of recurrences.
            Article 0 comments Cited 34 times – based on 0 reviews     Review now
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              Surveillance following radical or partial nephrectomy for renal cell carcinoma.

              Robert Figlin, Arie S. Belldegrun, Robert A Figlin … (2005)
              Renal cell carcinoma (RCC) is the most lethal of the common urologic malignancies, with approximately 40% of patients eventually dying of cancer progression. Approximately one third of patients present with metastatic disease and up to 50% treated for localized disease have a recurrence. Although the prognosis generally is poor in these patients, some may respond to immunotherapy and a subset of patients who develop solitary metastases can achieve long-term survival. Therefore, the timely identification of recurrences following surgical extirpation is imperative in the treatment of patients.
              Article 0 comments Cited 27 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Cureus
                Journal ID (iso-abbrev): Cureus
                Journal ID (issn): 2168-8184
                Title: Cureus
                Publisher: Cureus (Palo Alto (CA) )
                ISSN (Electronic): 2168-8184
                Publication date (Electronic, pub): 16 August 2021
                Publication date (Electronic, collection): August 2021
                Volume: 13
                Issue: 8
                Electronic Location Identifier: e17217
                Affiliations
                [1 ] Hematology and Oncology, Alabama Cancer Care (ALCC), Anniston, USA
                [2 ] Oncology, Atomic Energy Cancer Hospital (NORI), Islamabad, PAK
                Author notes
                Article
                DOI: 10.7759/cureus.17217
                PMC ID: 8442569
                SO-VID: 5d84d121-745a-4f15-bac8-5529081d2c78
                Copyright © Copyright © 2021, Hamid et al.
                License:

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                Date accepted : 16 August 2021
                Categories
                Subject: Internal Medicine
                Subject: Oncology
                Subject: Hematology

                Keywords: renal cell carcinoma,renal cell metastasis,metastasis,lung nodule,renal neoplasm
                Data availability:
                Keywords: renal cell carcinoma, renal cell metastasis, metastasis, lung nodule, renal neoplasm

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