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      Effect of Suckling on the in vivo Release of Thyrotropin-Releasing Hormone, Dopamine and Adrenaline in the Lactating Rat

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          Abstract

          The present study was concerned with the effect of suckling on the hypothalamic release of thyrotropin-releasing hormone (TRH), dopamine and adrenaline in lactating rats as estimated by push-pull perfusion of the median eminence-arcuate nucleus area. The push-pull cannula was implanted on day 15 of pregnancy. This surgery did not interfere with pregnancy, time of delivery or lactation. Push-pull perfusion was performed on day 8 or 14 of lactation and 30 out of 42 perfusions were successful. On the day of perfusion mothers and young were separated. Six hours later push-pull perfusion was begun and 6 samples at 15-min intervals were collected. In control animals, not allowed to nurse pups during perfusion, the release of TRH, dopamine and adrenaline did not change during the 90-min period. In experimental animals, reunited with their litter after 30 min of perfusion, the hypothalamic release of adrenaline did not change. However, both on day 8 and 14 suckling induced a 50% decrease in the release of dopamine (p < 0.025) which lasted for 15–30 min. Suckling on day 14 did not affect the concentration of TRH in the perfusate, but on day 8 the TRH output gradually decreased for 45 min after the onset of suckling.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1988
          1988
          02 April 2008
          : 48
          : 1
          : 93-96
          Affiliations
          aDepartments of Internal Medicine III and Clinical Endocrinology, and bEndocrinology, Growth and Reproduction, Faculty of Medicine, Erasmus University, Rotterdam, The Netherlands
          Article
          124995 Neuroendocrinology 1988;48:93–96
          10.1159/000124995
          3140046
          5d8fdd88-0c2f-425b-93c0-052acd3a0c4b
          © 1988 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 08 September 1987
          : 04 January 1988
          Page count
          Pages: 4
          Categories
          Original Paper

          Endocrinology & Diabetes,Neurology,Nutrition & Dietetics,Sexual medicine,Internal medicine,Pharmacology & Pharmaceutical medicine
          Push-pull perfusion,Hypothalamus,Suckling,Thyrotropin-releasing hormone,Prolactin,Adrenaline,Dopamine,Lactation

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