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      Detection of Hemodynamic Turbulence in Experimental Stenosis: An in vivo Study in the Rat Carotid Artery

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          Abstract

          In a previous study, we have demonstrated that turbulences in arteries less than 1.5 mm in diameter perfused ex vivo by an oscillated flow can be determined using nonlinear mathematical models. The hypothesis tested here was that nonlinear analyses enable the in vivo detection of turbulences in blood flow in vessels with dimensions affected by microsurgery. Twenty Wistar male rats were studied. After an intraperitoneal anesthesia (50 mg/kg sodium pentobarbital), each right carotid artery was dissected and a transit time flowmeter was used to measure blood flow. Arteries were studied in control conditions and graded stenoses, which were performed by a collar system and progressively increased from 0 to 95%. For each flow signal, time delay, false-nearest neighbors, correlation dimension and the largest Lyapunov exponent were computed to characterize the level of turbulence. The level of turbulence was highly correlated with the degree of stenosis induced (p < 0.001). The correlation dimensions of all the flow signals varied between 3 and 5, thus implying that more than three independent noninteger control variables were necessary to account for the complexity of rat carotid artery dynamics. Turbulence flow significantly increased in arteries with 40–95% stenosis. Nonlinear analysis may be useful to determine the turbulence level of an in vivo flow in arteries less than 1.5 mm in diameter and might be clinical useful for turbulence detection after microsurgery.

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          Most cited references 5

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          Characterization of Strange Attractors

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            Testing for nonlinearity in time series: the method of surrogate data

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              Determining embedding dimension for phase-space reconstruction using a geometrical construction

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                Author and article information

                Journal
                JVR
                J Vasc Res
                10.1159/issn.1018-1172
                Journal of Vascular Research
                S. Karger AG
                1018-1172
                1423-0135
                2002
                February 2002
                13 February 2002
                : 39
                : 1
                : 21-29
                Affiliations
                aLaboratoire d’Etude de la Microcirculation, Université Paris VII, Hôpital F.-Widal, bLaboratoire de Microchirurgie Expérimentale, Université Paris VII, Faculté Villemin-St-Louis, et cService de Chirurgie Plastique Reconstructrice et Esthétique, Hôpital St-Louis, Paris, France
                Article
                48990 J Vasc Res 2002;39:21–29
                10.1159/000048990
                11844934
                © 2002 S. Karger AG, Basel

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                Page count
                Figures: 8, References: 39, Pages: 9
                Categories
                Research Paper

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